Kyoto Pharmaceutical Industries, Ltd.

Sumitomo Dainippon Pharma Co., Ltd.

Kyoto Pharmaceuticals Industries, Ltd.

Shigemitsu Takeda

Yoshimichi Shoji

Masayasu Kasai

Yoshinobu Yoshimura

Hiroaki Shirahase

Tatsuya Kitao

Kenji Takahashi

The problem of the present invention is to provide a useful prodrug compound of a naphthofuran compound. The present invention relates to a compound represented by the formula (IA): [wherein each symbol is as described in the DESCRIPTION] or a pharmaceutically acceptable salt thereof.

Anticancer agent

The present invention aims to provide a novel cyclin-dependent kinase 8 and/or 19 inhibitor useful as an anti-cancer agent. The present invention relates to a cyclin-dependent kinase 8 and/or 19 inhibitor containing a compound represented by the formula (I): [wherein each symbol is as defined in the DESCRIPTION] or a pharmaceutically acceptable salt thereof as an active ingredient, and use thereof as an agent for preventing and/or treating cancer.

Cyclin-dependent kinase 8 and/or 19 inhibitor

Provided is a compound showing a bone formation promoting action (and/or bone resorption suppressive action). A compound of the formula (I) or a pharmacologically acceptable salt: [wherein each substituent is as defined in the DESCRIPTION], has low toxicity, shows good pharmacokinetics, has an action to promote bone formation, and is useful for the prophylaxis or treatment of metabolic bone diseases (osteoporosis, fibrous osteitis (hyperparathyroidism), osteomalacia, Paget's disease that influences the systemic bone metabolism parameter etc.) associated with a decrease in the bone formation ability as compared to the bone resorption capacity.

Aromatic compound and use thereof

Growing community of inventors

Kyoto, Japan

Shigemitsu Takeda