Eisai Company, Limited

Sansho Co., Ltd.

Shigemitsu Osawa

Yutaka Morita

Yoshio Tanabe

Tomohide Tanaka

Kana Satoh

Itaru Sakai

Takashi Hibi

Yasushi Tomita

Masanori Kayano

Mitsuhiro Yoshida

Masayoshi Kasai

Hiroyuki Fujimori

Hidenori Asakawa

A whitening embellisher includes, as an active ingredient, teprenone (chemical name: geranylgeranyl-acetone). A whitening and beautifying composition includes teprenone and one or more substances selected from kojic acid, L-ascorbic acid and the like. The whitening embellisher, and whitening and beautifying composition prevent the skin from pigmenting and darkening due to sunburn and/or aging, and quicken fading, and hence make spots and freckles inconspicuous when the preparations are used for external application as a cream or milky lotion.

Whitening embellisher

A whitening embellisher includes, as an active ingredient, teprenone (chemical name: geranylgeranylacetone). A whitening and beautifying composition includes teprenone and one or more substances selected from kojic acid, L-ascorbic acid and the like. The whitening embellisher, and whitening and beautifying composition prevent the skin from pigmenting and darkening due to sunburn and/or aging, and quicken fading, and hence make spots and freckles inconspicuous when the preparations are used for external application as a cream or milky lotion.

A pharmaceutical composition comprises (a) a pharmacologically effective amount of bunazosin or a pharmacologically acceptable salt thereof and (b) a monoglyceride of a fatty acid having 8 to 12 carbon atoms and/or a lactic acid ester of an aliphatic alcohol having 12 to 18 carbon atoms and is improved in percutaneous administration. ##STR1##

Pharmaceutical preparation for percutaneous administration containing

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Saitama, Japan

Shigemitsu Osawa