Ajinomoto Co., Ltd.

Shigemitsu Abe

Yasuo Yonou

Naoto Hirano

Toshiya Tanabe

Tetsuya Kawakita

Toyokazu Kaneko

Masazumi Date

Kunihiko Toumori

Shinya Tachibana

Disclosed herein are a process for producing mixed crystals of disodium 5'-guanylate and disodium 5&#x2032;-inosinate which comprises precipitating mixed crystals of disodium 5&#x2032;-guanylate and disodium 5&#x2032;-inosinate (I+G mixed crystals) by adding an aqueous mixed solution of disodium 5&#x2032;-guanylate and disodium 5&#x2032;-inosinate and a hydrophilic organic solvent at the same time into a crystallization vessel in such manner that the ratio of the hydrophilic organic solvent to the liquid phase in the crystallization vessel is maintained in a range of 30 to 70 vol %, as well as such process for producing I+G mixed crystals wherein said producing of I+G mixed crystals is carried out by seeding crystallization wherein crystals of 5&#x2032;-IMP2Na or/and I+G mixed crystals are used as seed crystals. According to these production processes, the by-production of amorphous solids of 5&#x2032;-GMP2Na which adversely affect separability of the crystals concerned, is inhibited, and therefore, such mixed crystals having a good separability without contamination of such amorphous solids, can be produced in a high productivity.

Method for producing mixed crystal of disodium 5'-guanylate and disodium 5&#x2032;-inosinate

Herein is disclosed a method for producing mixed crystals of disodium 5&prime;-guanylate and disodium 5&prime;-inosinate which comprises feeding a mixed solution of disodium 5&prime;-guanylate and disodium 5&prime;-inosinate which solution will become supersaturated at the below-mentioned constant temperature, to a solution or slurry of disodium 5&prime;-guanylate and disodium 5&prime;-inosinate charged in a crystallization bath (lower-temperature bath) and kept at a constant temperature, whereby mixed crystals of disodium 5&prime;-guanylate and disodium 5&prime;-inosinate are deposited from the mixed solution of disodium 5&prime;-guanylate and disodium 5&prime;-inosinate, according to which method 5&prime;-GMP2Na which is difficult to handle due to the properties and powder characteristic of its crystals in particular and 5&prime;-IMP2Na, in the form of crystals which are easy to handle, that is, I&plus;G mixed crystals having a given I/G ratio, can be produced under simple process control and with inexpensive facilities, with the I/G ratio being controlled easily.

Method for producing mixed crystals of disodium 5&prime;-guanylate and disodium 5&prime;-inosinate

A method for separating electrolytes which have different charges of the same sign or of carrying out ion exchange of electrolytes with counterions, which comprises causing the electrolytes (anion or cation) to pass through a positively or negatively charged loose reverse-osmotic membrane, in an aqueous solution.

Method for separation of electrolytes, and method for ion exchange of

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Kawasaki, Japan

Shigemitsu Abe