National Institute of Advanced Industrial Science and Technology

Seikagaku Corporation

Shigemi Sugioka

Hisashi Narimatsu

Hideo Mochizuki

Yasunori Chiba

Yoshifumi Jigami

Aruto Yoshida

Hiroshi Manya

Tamao Endo

Yoriko Takeuchi, Legal Representative

A glycosaminoglycan sulfotransferase, a peptide thereof, a nucleic acid comprising a nucleotide sequence encoding the same, an enzyme agent for the synthesis of a glycosaminoglycan, which comprises the above-described enzyme or polypeptide, and a process for producing a glycosaminoglycan, which uses the enzyme agent.

Sulfotransferase, peptide thereof and DNA encoding the same

Sulfotransferase, its polypeptide and DNA encoding the same

The present invention relates to an enzyme having novel N-acetylglucosaminyltransferase (OMGnT) activity, a polynucleotide encoding the enzyme, a recombinant polynucleotide comprising the polynucleotide, a host cell comprising the recombinant polynucleotide, a method for producing an enzyme protein having OMGnT activity by culturing the host cell in a medium, and a method for modifying a sugar chain structure with the enzyme and a carbohydrate having a sugar chain structure modified by the method. This enzyme enables the production of complex carbohydrates, which could not be formed with conventional glycosyltransferases.

N-acetylglucosaminlytransferase and polynucleotide encoding the same

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Tsukuba, Japan

Shigemi Sugioka