Case Western Reserve University

Shigemi Matsuyama

William Greenlee

A compound having formula (I) or (II) for use inhibiting Bax mediated cell death and/or apoptosis.

Bax inhibitors and uses thereof

A method of inhibiting &#x3b2;-amyloid (A&#x3b2;) induced neuronal cell death includes administering to a neuronal cell exposed to a neurotoxic amount of A&#x3b2; a therapeutically effective amount of cell penetrating peptide (CPP). The CPP has an amino acid sequence that has at least 80% sequence identity to about 5 to about 41 consecutive amino acids of SEQ ID NO: 1.

IFN&#x3b3;R2 compositions and methods of inhibiting neuronal cell death

A method of inhibiting apoptosis in a cell includes administering to a cell an effective amount of a cell penetrating peptide (CPP), wherein the CPP consists of about 5 to about 41 amino acids and is substantially homologous to a portion of the C-terminal region of IFN&#x3b3;R2.

Interferon gamma receptor beta chain compositions and methods of inhibiting apoptosis

A method of treating chemotherapy-induced thrombocytopenia includes administering to a subject undergoing chemotherapy a therapeutically effective amount of a Bax-inhibiting peptide.

Growing community of inventors

Beachwood, OH, United States of America

Shigemi Matsuyama