Yamanouchi Pharmaceutical Company Ltd.

Shigemi Kawahara

Masuo Murakami

Jun Sekino

Hidemi Shimizu

Kiyoshi Okazaki

Hiroitsu Kawata

Hiroitsu Kawada

There is disclosed a dry, stabilized oral pharmaceutical formulation containing a prostaglandin E group prepared from a lyophilized composition comprising a prostaglandin E group and at least a member selected from the group consisting of a thiol compound, dextrin, dextran, a lower alkyl cellulose, and a water-soluble salt of deoxycholic acid.

Stabilized oral prostaglandin formulation and the process for the

There is provided a process of preparing a prostaglandin E group-containing formulation by adding to a prostaglandin E group at least one additive selected from the group consisting of thiol compound, a water-soluble high molecular weight compound, and a water-soluble salt of deoxycholic acid and then subjecting the mixture to lyophilization.

Process of preparing stable prostaglandin E group-containing formulation

There is provided a process of preparing a prostaglandin E group-containing formulation by adding to a prostaglandin E group at least one additive selected from the group consisting of a thiol compound, a water soluble high molecular weight compound and a water-soluble salt of deoxycholic acid and then subjecting the mixture to lyophilization.

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Higashikurume, Japan

Shigemi Kawahara