Other

Kyowa Hakko Kogyo Co., Ltd.

Nihon University

Shigemasa Sawada

Satoshi Nakagawa

Tatsunari Nishi

Tetsuro Kuga

Mikiko Sakurada

Tetsuyoshi Ishiwata

Masami Takei

Ayako Kawabata

Kenji Shibata

Akiko Furuya

Takahiro Nagase

Ayako Nishimura

Nobuo Nomura

A novel DNA whose expression level fluctuates in leukocytes of IgA nephropathy patients in comparison with leukocytes of healthy persons, a process for isolating the DNA, a novel protein encoded by the DNA, an antibody recognizing the protein, methods for detecting the protein and the DNA, and methods of diagnosis and treatment of IgA nephropathy.

IgA nephropathy-related DNA

The present invention relates to a novel DNA related to IgA nephropathy obtained by a differential display method &lsqb; , 351, 231 (1994)&rsqb; taking note of an mRNA whose expression level fluctuates in leukocytes of IgA nephropathy patients in comparison with leukocytes of healthy persons, a process for isolating the DNA, a method for detecting the DNA, a novel protein encoded by the DNA, an antibody recognizing the protein, a method for detecting the protein, and diagnosis and treatment of IgA nephropathy.

IGA nephropathy-related genes

The present invention relates to a novel protein isolated from the leukocyte of IgA nephropathy patients, and DNA encoding the protein. It also relates to an oligonucleotide based on the nucleotide sequence complementary with the DNA, an antibody which specifically reacts with the protein and, furthermore, diagnostic and therapeutic drugs of IgA nephropathy comprising it.

DNA encoding IGA nephropathy indicating protein

Growing community of inventors

Tokyo, Japan

Shigemasa Sawada