Shibuya Corporation

Shigeki Koishi

Yukinobu Nishino

Katsunori Tanikawa

Koji Kaya

Masaaki Eda

Kengo Ikeda

Toshiaki Naka

Akira Hatanaka

A liquid containing exosomes is filtered through a first filter that has a hole diameter that passes the exosomes and blocks cells, and is then stored in a first storage unit (rough filtration step). Next, pressure is applied to the inside of the first storage unit to pump the liquid to a pre-filtration chamber in a second filter that blocks the exosomes so that water in the liquid is filtered out into a post-filtration chamber. The exosome-containing liquid that was not filtered out is returned to the first storage unit, thereby increasing the exosome concentration in the liquid for extraction (concentration step). The exosome-containing concentrate in the first storage unit is then filtered through a third filter having a hole diameter that passes the exosomes and blocks bacteria, and is sent to a recovery unit (sterilization filtration step).

Exosome extraction device and exosome extraction method

A filling system includes a center wheel that conveys vessels, a first filler provided with a plurality of filling heads, a second filler provided with a plurality of filling heads and arranged downstream from the first filler, a first inlet wheel that receives the vessels from the center wheel and supplies the vessels to the first filler, and a second inlet wheel that receives the vessel from the center wheel and supplies the vessels to the second filler. Operation modes are switchable between a first operation mode that conveys the vessels to the first filler and a second operation mode that conveys the vessels to the second filler instead of conveying to the first filler by controlling the reception of the vessels at the first and second inlet wheels.

Filling system

A filling system includes a conveyance chamber that conveys vessels, a filling chamber provided with a filling head that fills content into the vessels, a pressure control means that controls the pressure conditions of each chamber, an intermediate chamber that is provided between the conveyance chamber and the filling chamber, and a shutter that can separate the conveyance chamber and the intermediate chamber. When the filling chamber is separated by the shutter, the pressure control means controls the pressure of the intermediate chamber to become lower than the pressure of the conveyance chamber and the filling chamber.

A filling system includes a conveyance chamber in which a center wheel for conveying vessels is housed inside, a filling chamber where filling machines are housed inside, an inlet/outlet wheel that transfers the vessels from the center wheel to the filling machine, an opening that allows conveyance of the vessels, and a shutter that closes the opening. The inlet/outlet wheel includes grippers configured from a fixed section and a movable section. The movable section can be raised or lowered with respect to the rotational axis of the inlet/outlet wheel. When the shutter closes the opening, movable section is raised or lowered by a predetermined amount relative to the fixed section, after which the movable section is rotated by a predetermined amount to a position where it does not interfere with the shutter.

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Ishikawa, Japan

Shigeki Koishi