Dainippon Pharmaceutical Company, Limited

Carna Biosciences, Inc.

National Cancer Center

Mychunter Therapeutics, Inc.

Shigeki Kashimoto

Masaaki Sawa

Shinichi Nakamura

Tesshi Yamada

Takayuki Irie

Tokiko Asami

Katsumi Chiba

Hideki Moriyama

Yuko Uno

Takao Kiyoi

Wataru Kawahata

Yuzo Sakaguchi

Shin-ichi Matsumoto

Kyoji Tomita

Koh-ichiro Shibamori

Yasunori Tsuzuki

An oxoisoquinoline compound of the following formula: or a pharmaceutically acceptable salt thereof; a pharmaceutical composition comprising the oxoisoquinoline compound or salt; and a method for treating B-cell lymphoma comprising administering the oxoisoquinoline compound or salt to a patient.

Oxoisoquinoline derivatives

The present invention provides a quinazoline derivative represented by the following formula (I): wherein Rand Rrepresent a hydrogen atom, a halogen atom, or a lower alkyl group optionally having a substituent; Z represents a cycloalkyl group having a substituent or a cycloalkenyl group having a substituent; and Q represents a bicyclic heteroaryl group optionally having a substituent, or a pharmaceutically acceptable salt thereof. Since the compound has an inhibitory effect on the Wnt/&#x3b2;-catenin signaling pathway and exhibits an antitumor effect, it is useful as a medicine.

Quinazoline derivative

Compounds, processes for the preparation thereof and anti-tumor agents

A method of preventing or eliminating mycoplasma contamination of animal or plant cell cultures, which comprises adding an anti-mycoplasmally effective amount of 5-amino-7-(2-aminomethylmorpholino)-1-cyclopropyl-6, 8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid or its salt to a culture medium in which animal or plant cells are cultivated; and an agent or a preparation for preventing or eliminating mycoplasma contamination of animal or plant cell cultures, comprising 5-amino-7-(2-aminomethylmorpholino)-1-cyclopropyl-6, 8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid or its salt.

Prevention or elimination of mycoplasma contamination of animal or plant

Growing community of inventors

Osaka, Japan

Shigeki Kashimoto