The University of Tokyo

Shigehito Osawa

Kanjiro Miyata

Kazunori Kataoka

Yasutaka Anraku

Hiroyuki Chaya

Mitsuru Naito

Meng Zheng

Beob Soo Kim

A drug-polymer conjugate having thermoresponsiveness includes at least one drug conjugated to at least one end portion of at least one thermoresponsive polymer segment having a lower critical solution temperature. The drug-polymer conjugate is capable of forming a micellular aggregate in an aqueous medium at temperatures equal to or above the lower critical solution temperature. The drug-polymer conjugate or the micellular aggregate thereof may be administered to and absorbed in the lungs.

Temperature-responsive drug/polymer compound and application of compound to drug delivery

Provided are a micelle composition for nucleic acid delivery using a temperature-sensitive polymer, and a method for producing the micelle. For example, provided is a polyion complex comprising a temperature-sensitive copolymer and a nucleic acid, wherein the temperature-sensitive copolymer comprises a cationic block and a temperature-sensitive block, the cationic block optionally carrying a hydrophilic block linked thereto, and the polyion complex is obtained by mixing the temperature-sensitive copolymer with the nucleic acid under temperature conditions equal to or lower than the lower critical solution temperature (LCST) of the temperature-sensitive copolymer.

Micelle composition for nucleic acid delivery using temperature-sensitive polymer and method for producing same

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Tokyo, Japan

Shigehito Osawa