Toray Industries, Inc.

Shigehisa Wada

Hidetoshi Kozawa

Kazuhiro Tanahashi

Hiroshi Takahashi

Hiroyuki Sugaya

Jun Utsumi

Hidekazu Nakashima

Kazuo Teramoto

Ichiro Kumo

Giman Jung

Masaaki Shimagaki

Yasufumi Yamamura

Toshihiko Kuroda

Nobuyuki Kuroki

Satoko Yamada

Katsuhisa Sato

Takeshige Oozeki

Shuji Sekiguchi

Yoshiji Fujita

Giman Toray Koshigoe-Shataku Jung

Shuji Moriguchi-Kata Sekiguchi

Toshihiko Toray Kamakurayama-Ryo 401 Kuroda

The present invention provides an absorbent which can remove cells present in blood including activated leukocytes such as granulocytes and monocytes, and cancer cells as well as can remove cytokines which facilitate the activation of the remaining cells, and further has no concern for pressure loss and has high configuration stability. That is, the present invention provides an absorbent which absorbs the granulocytes and the monocytes in blood, an absorbent for cancer therapy which absorbs an immunosuppressive protein and an absorbent having a bilayer structure of a net and a nonwoven fabric, having a zeta potential of &#x2212;20 mV or more, as well as a blood circulation column containing any of the absorbents filled therein.

Absorbent and column for extracorporeal circulation

The following is disclosed: (1) a membrane fractionator including a filtration section, a concentrating section, a recovery section and a liquid feed pump, wherein a flow channel connecting the filtration section, concentrating section and recovery section to each other constitutes a closed circuitry; (2) a method of biocomponent separation, characterized in that a sample derived from biocomponents is fed into an antibody adsorption membrane separation system having an antibody capable of adsorbing specified protein internally accommodated in the middle or a rear part of a membrane separation system that in the absence of antibodies adsorbing proteins, exhibits a permeation ratio between human alpha1-microglobulin and human albumin of 1.5 to 1000, thereby separating part of the biocomponents; and (3) a method of protein fractionation, comprising bringing a solution containing two or more types of proteins and water into contact with a hollow yarn separation membrane to thereby attain protein fractionation, characterized in that the fractionation solution contains an organic solvent.

Fractionator and method of fractionation

A dialyzer for blood treatment including a semipermeable membrane which is made of a hydrophobic polymer and a hydrophilic polymer, and has a water permeating performance drying of &#xbd; or higher relative to that before drying. The dialyzer has a vitamin B12 clearance not smaller than 135 ml/mm per 1.6 mor the amount of the hydrophilic polymer eluted from the semipermeable membrane is not higher than 10 ppm. A dialyzer for blood treatment is light-weight, easy to handle, and exhibits a reduced elution of the hydrophilic polymer procedures for producing a dialyzer containing the semipermeable membrane and a process for producing a hollow fiber membrane for use in blood treatment are described.

Dialyzers for blood treatment and processes for production thereof

A dialyzer for blood treatment includes a semipermeable membrane which is made of a hydrophobic polymer and a hydrophilic polymer, and has a water permeating performance drying of &frac12; or higher relative to that before drying. The dialyzer has a vitamin B12 clearance not smaller than 135 ml/min per 1.6 m or the amount of the hydrophilic polymer eluted from the semipermeable membrane is not higher than 10 ppm. A dialyzer for blood treatment is light-weight, easy to handle, and exhibits a reduced elution of the hydrophilic polymer procedures for producing a dialyzer containing the semipermeable membrane and a process for producing a hollow fiber membrane for use in blood treatment as described.

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Shiga, Japan

Shigehisa Wada