Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo

Hayashibara Co., Ltd.

Other

Kabashiki Kaisha Hayashibara Seibutsu Kagaku

Shigeharu Fukuda

Toshio Miyake

Michio Kubota

Tomoyuki Nishimoto

Kazuyuki Oku

Hiroto Chaen

Takashi Shibuya

Hikaru Masahiro Watanabe

Takuo Yamamoto

Keiji Tsusaki

Hajime Aga

Seisuke Izawa

Masashi Kurimoto

Kazuhiko Maruta

Keizo Kohno

Takanobu Higashiyama

Kakuji Torigoe

Toshio Kunikata

Shimpei Ushio

Tatsuya Ishihara

Kazuhisa Mukai

Haruki Okamura

Mutsuko Taniguchi

Takeshi Ario

Takanori Okura

Hajime Kusano

Katsuhiko Hino

Emiko Ohashi

Toshiharu Hanaya

Todao Tanimoto

Keji Tsusaki

Hikaru Watanabe

Tadao Tanimoto

Tsunetaka Ohta

Toshio Ariyasu

Yoshikatsu Miwa

Shigeyuki Arai

Harumi Ariyasu

Mayumi Kurose

Shinichiro Inoue

Tomohiko Sonoda

Satomi Miyata

Chie Ushio

Tohru Kayano

Keiko Hino

Takeo Sakurai

Tohru Ogawa

Fujimi Tanabe

Rohko Yamamoto

Hiromi Tatsukawa

Takanori Ohkura

Keiko Takeda

Sae Murai

Kenshi Yoshida

Ikuo Sawatani

Masahiro Yagi

Naoki Kudo

Yasuo Suemoto

Hitomi Ohta

The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.

Process for producing a particulate composition comprising an hydrous crystalline 2-o-alpha-d-glucosyl-ascorbic acid

The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched &#x3b1;-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows:

Branched alpha-glucan, alpha-glucosyltransferase which forms the glucan, their preparation and uses

The present invention aims to provide an external dermal composition for anti-ageing, which prevents or improves apparent skin problems such as age-related or senescent wrinkles, fine wrinkles, saggings, spots, etc., as well as maintaining or enhancing the skin barrier functions. The object is solved by providing an external dermal agent for anti-ageing, which contains as an effective ingredient(s) one or more members selected from the group consisting of adenosine N1-oxide 5'-phosphate, analogs thereof, and their salts.

External dermatological agent for anti-ageing

Process for producing a particulate composition comprising an hydrous crystalline 2-O-&#x3b1;-D-glucosyl-L-ascorbic acid

The present invention has an object to provide an effective and safe therapeutic agent for inflammatory diseases such as sepsis, hepatitis, and inflammatory bowel disease, and solves the above object by providing a therapeutic agent for inflammatory diseases containing adenosine N1-oxide or a derivative thereof as an effective ingredient.

Therapeutic agent for inflammatory diseases, containing adenosine N1-oxide as an effective ingredient

Branched &#x3b1;-glucan, &#x3b1;-glucosyltransferase which forms the glucan, their preparation and uses

The present invention has an object to provide an external dermal agent with a sustainable anti-wrinkle action, which has both the action of enhancing the proliferation and differentiation of keratinocytes in the skin and the action of enhancing the collagen production in the skin, and which assists the maintenance and the improvement of tissue structures and physiological functions of the epidermis and the dermis, whereby providing a remarkable skin improvement effect. The present invention solves the above object by providing an external dermal agent containing &#x3b1;-D-glucopyranosyl-(1&#x2192;3')-adenosine and/or &#x3b1;-D-glucopyranosyl-(1&#x2192;5&#x2032;)-adenosine as an effective ingredient(s).

External preparation for skin

Process for producing a particulate composition comprising anhydrous crystalline 2-O-alpha-D-glucosyl-L-ascorbic acid

The objects of the present invention are to provide a method for inhibiting the coloration of a syrupy sweetener, comprising a reducing saccharide together with a non-reducing oligosaccharide having a &#x3b2;-fructofuranosidic linkage, without deteriorating the taste inherent to the syrupy sweetener; and to provide a syrupy sweetener, comprising a reducing saccharide together with a non-reducing oligosaccharide having a &#x3b2;-fructofuranosidic linkage, which is stabilized by the method. The present invention attains the above objects by providing a method for inhibiting the coloring of a syrupy sweetener, comprising a reducing saccharide together with a non-reducing oligosaccharide having a &#x3b2;-fructofuranosidic linkage, which comprises a step of incorporating a lactate into the syrupy sweetener, and by providing a syrupy sweetener, comprising a reducing saccharide together with a non-reducing oligosaccharide having a &#x3b2;-fructofuranosidic linkage, which is stabilized by the method.

Method for inhibiting coloring of a syrupy sweetener comprising a non-reducing oligosaccharide having a beta-fructofranosidic linkage and a reducing saccharide, and use thereof

The present invention has objects to provide a novel crystalline 2-O-&#x3b1;-glucosyl-L-ascorbic acid and its production process and uses, and solves the above objects by providing hydrous crystalline 2-O-&#x3b1;-glucosyl-L-ascorbic acid, a particulate composition containing hydrous crystalline 2-O-&#x3b1;-glucosyl-L-ascorbic acid, and their production processes and uses.

Hydrous crystalline 2-O-&#x3b1;-D-glucosyl-L-ascorbic acid, particulate composition comprising the same, their preparation and uses

The present invention has objects to provide a thermostable cellobiose 2-epimerase, its preparation and uses. The present invention attains the above objects by providing a thermostable cellobiose 2-epimerase, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a process for producing the enzyme, and a process for producing isomerized saccharides using the enzyme.

Cellobiose 2-epimerase, its preparation and uses

The present invention has an object to provide a fluid for peritoneal dialysis with satisfactory body fluid removability, high biocompatibility, and improved storage stability, and the object is attained by a fluid for peritoneal dialysis containing one or more saccharides selected from cyclonigerosylnigerose, cyclomaltosylmaltose, and L-ascorbic acid 2-glucoside.

Fluid for peritoneal dialysis

Growing community of inventors

Okayama, Japan

Shigeharu Fukuda