Sanwa Kagaku Kenkyusho Co., Ltd.

Shigeaki Yoshina

Tsutomu Ishida

Noboru Tomiya

Hitoshi Noda

Makoto Sato

Toshiyuki Kouzaki

Tatsushi Maeda

Masanao Nakoshi

Yoko Ishihara

Hidehumi Yamakawa

A pharmaceutical composition is disclosed comprising a fat emulsion containing microspheres and having its electric charge adjusted to a negative value and a biologically active substance selected from the group consisting of a basic peptide and a basic protein, which biologically active substance is adsorbed to the microspheres in the fat emulsion. An acidic phospholipid, a fatty acid, a bilic acid and a salt of such substances is preferred as an agent for adjusting the electric charge of the fat emulsion. Motilin derivatives, vasoactive intestinal polypeptide derivatives and calcitonin are preferred biologically active substances.

Pharmaceutical composition containing biologically active peptide or

The invention provides a polypeptide of calcitonin analogue and use thereof. The polypeptide has such an amino acid sequence that proline-amide residue (Pro-NH.sub.2) at C-terminal of native eel calcitonin is substituted to a homoserine amide residue (Hse.multidot.NH.sub.2).

Calcitonin analogue and use thereof

The modified polypeptide compound of the present invention is represented by the following general formula ((SEQ ID NO: 2)-X):

Modified polypeptide compound with VIP-like activity

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Nagoya, Japan

Shigeaki Yoshina