Kureha Kagaku Kogyo Kabushiki Kaisha

Kureha Chemical Industry Company, Limited

Shigeaki Muto

Chikao Yoshikumi

Takao Furusho

Takao Ando

Akihiko Kanno

Takayoshi Fujii

Kouichi Niimura

Kenichi Matsunaga

Koichi Niimura

Masahiko Fujii

Masaaki Takahashi

Masanori Ikuzawa

Yuji Maeda

Yoshiharu Oguchi

Kunitaka Hirose

Isamu Motokawa

Tamotsu Kanoh

Norifumi Sugita

Yoko Onishi

Junji Kakuchi

Minoru Oohara

A multi-functional physiologically active substance can be obtained from the residue of saccharified malt which has been worthless other than feed for cattle. The isolation of the active substance is performed by an extraction of the residue with water or an aqueous solvent and removal of a low molecular weight fraction from the extract.

Physiologically active substance derived or malt and process for the

A multi-functional physiologically active substance can be obtained from the residue of saccharified malt which is worthless other than feed for cattle. The isolation of the active substance is performed by an extraction of the residue with water or an aqueous solvent and removal of a low molecular weight fraction from the extract.

Physiologically active substance derived from malt and process for the

Disclosed herein are polysaccharides extracted from marine algae and an antiviral drug containing as active ingredient polysaccharides extracted from seaweeds.

Polysaccharides and antiviral drugs containing the same as active

Disclosed herein are lectins extracted form a plant of the class Dicotyledoneae and an antiretoviral drug comprising as an active ingredient an effective amount of the lectins.

Lectins and antiretroviral drugs containing the lectins as active

Disclosed herein are the derivatives of substituted cephalosporanic acid represented by the formula (I): ##STR1## wherein R.sup.1 represents a 4-pyridylthiomethyl group, an alpha-aminobenzyl group, a cyanomethyl group or a 1-tetrazolylmethyl group; R.sup.2 represents a hydrogen atom, an acetoxy group or a (5-methyl-1,3,4-thiadiazol-2-yl)thio group; R.sup.3 represents a hydrogen atom, a hydroxyl group, a carbamoyl group, an alkyl group having 1 to 4 carbon atoms or --(CONH).sub.m (CH.sub.2).sub.n --COOH wherein m is 0 or 1, n is 0, 1 or 2 and the carboxyl group may have been converted to a salt or an ester thereof; p is 0, 1 or 2 and X represents carbon atom or nitrogen atom, and antibiotics comprising the derivatives of substituted cephalosporanic acid represented by the formula (I).

N-(substituted)-[7-(2-cyanoacetamido)cephalosporanic]amide derivatives

Disclosed herein are a cephalosporin derivative represented by the formula (I): ##STR1## wherein R.sup.1 represents a halogenoalkyl group, a salt and ester thereof, a process for producing the same, and a pharmaceutical composition and an antibacterial agent comprising the same.

Cephalosporin derivative, process for producing the same and

Disclosed herein are a derivative of a substituted cephalosporanic acid, represented by the formula (I): ##STR1## wherein p is 0, 1 or 2 and R.sup.1 represents a hydrogen atom, a hydroxyl group, a carbamoyl group, an alkyl group having 1 to 4 carbon atoms or --(CONH).sub.m (CH.sub.2).sub.n --COOH wherein m is 0 or 1; n is 0, 1 or 2 and the carboxyl group may have been converted to the salt or the ester thereof, and an antibiotic comprising a derivative of substituted cephalosporanic acid represented by the formula (I).

Derivative of cephalosporanic acid and pharmaceutical composition

Disclosed herein are 7-beta-[2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]-3-(2-amino-1,3,4- thiadiazolyl-5-thiomethyl)-3-cepheme-4-carboxylic acid, salts thereof and pivaloyloxymethyl ester thereof, and a pharmaceutical composition containing the same as an active ingredient.

Pivaloyloxymethyl

A penicillin derivative having an antibacterial activity similar to a penicillin antibiotic in a living body without affecting the intestinal bacterial colonies, a process for preparing the derivative and a pharmaceutical composition in a dosage unit form containing the derivative as an active ingredient are disclosed.

Penicillin derivative

A cephalosporin derivative having an antibacterial activity similar to a cephalosporin antibiotic in living bodies without affecting the intestinal bacterial colonies, a method for preparing the derivative and a pharmaceutical composition in a dosage unit form containing the derivative as an active ingredient are disclosed.

Cephalosporin derivative

A compound having the general formula (I) is derived from a cephalosporin; ##STR1## wherein R' is a hydrogen atom, an alkyl group having 1 to 4 atoms or an alkali metal and R is --CH.sub.2 COOR', --CH.sub.2 CH.sub.2 SR', ##STR2## or --CH.sub.2 CH.sub.2 COOR' wherein R' is defined above. A pharmaceutical composition containing the compound is excellent in an antibacterial activity, the activity being recovered by the action of an activating enzyme in a living body although the compound per se shows a low activity against the beneficial bacterial colonies in a living body.

Cephalosporin derivative and pharmaceutical composition containing the

A compound having the general formula (I) is derived from a cephalosporin; ##STR1## wherein R' is a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or an alkali metal. A pharmaceutical composition containing the compound is excellent in an antibacterial activity, the activity being recovered by the action of an activating enzyme in a living body although the compound per se shows a low activity against the beneficial bacterial colonies in a living body.

Growing community of inventors

Tokyo, Japan

Shigeaki Muto