Nippon Shinyaku Company, Ltd.

Shigeaki Maruo

Yohji Ezure

Yoji Ezure

Makoto Sugiyama

Masao Murase

Katsunori Miyazaki

Hiroshi Enomoto

Yoshiaki Aoyagi

Yoshiaki Yoshikuni

Nobutoshi Ojima

Masashi Yamamoto

Hiroshi Yamashita

Kiyotaka Konno

Shingo Matsumura, Deceased

Naoyoshi Yamada

Noriyuke Tachikake

Process for producing saccharides

The present invention relates to stabilizing agents for enzymes which comprises an enzyme stabilizing amount of an N-substituted moranoline derivative of the formula (III): ##STR1## wherein R.sup.1 is phenyl lower alkynyl, phenoxy lower alkenyl or phenoxy lower alkynyl, wherein the phenyl moiety is unsubstituted, or a glucose oligomer thereof.

Moranoline derivatives and their production and the use of moranoline

A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof, wherein Y is S or O;

Quinoline substituted oxomethyl or thioxomethyl glycine derivatives and

A method of preparing a molecular compound of glucosylmoranoline of the formula I ##STR1## with methanol, which comprises stirring an aqueous solution comprising (I) and other moranoline derivatives with methanol, whereupon crystals of the molecular compound of (I) with methanol are formed.

Method of manufacturing moranoline derivatives

A compound of the formula (I): ##STR1## wherein R is hydrogen or unsubstituted or substituted 1-naphthyl. These compounds are useful to obtain inhibition of aldose reductase in animals, including humans.

Glycine derivatives

Bisglucosyl moranoline of the formula (I) ##STR1## is useful in inhibiting increase of blood sugar in sugar-loaded animals and humans, and particularly for treatment of diabetes mellitus.

Moranoline derivatives

Growing community of inventors

Osaka, Japan

Shigeaki Maruo