Xenon Pharmaceuticals Inc.

Novartis Ag

Shifeng Liu

Shaoyi Sun

Rajender Kamboj

Serguei Sviridov

Vishnumurthy Kodumuru

Jianmin Fu

Nagasree Chakka

Sultan Chowdhury

Zaihui Zhang

Mikhail A Chafeev

Vandna Raina

Heinz W Gschwend

Jianyu Sun

Duanjie Hou

Melwyn A Abreo

Michael D Winther

Wenbao Li

Chi Tu

Mehran Seid Bagherzadeh

Tom Hsieh

Alla Yurevna Zenova

Mark W Holladay

Mark Wood

Daniel F Harvey

Jonathan David Langille

Qi Jia

Simon James Gauthier

Jean-Jacques Alexandre Cadieux

Jian-Min Fu

Natalie Alysia Dales

Natalia Pokrovskaia

Thilo Focken

Mikhail Kondratenko

Lauren Fraser

Robert Fraser

Amy Frances Douglas

Zoran Cikojevic

Julia Fonarev

Sengen Sun

Cindy J Hudson

Kashinath Sadalapure

Mehran Bagherzadeh

Renata Marcella Oballa

Navjot Chahal

Heinz Gschwend

Mikhail A Kondratenko

Jian-min Fu

Mikhail Chafeev

Mikhail Chafev

Rajender K Kamboj

Kashinath Sadalupure

Sun Shaoyi

Michael Winther

This invention is directed to biaryl ether sulfonamides, or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

Biaryl ether sulfonamides and their use as therapeutic agents

This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

Spiro-oxindole compounds and their use as therapeutic agents

This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein k, j, Q, R, R, R, R, R, R, R, R, and Rare as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment and/or prevention of hypercholesterolemia, benign prostatic hyperplasia, pruritis and cancer. 

Use of spiro-oxindole compounds as therapeutic agents

Spiro-oxindole compounds and their uses as therapeutic agents

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): 

Pyridyl derivatives and their use as therapeutic agents

The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.

Organic compounds

A method of treating an SCD-mediated disease or condition in a mammal, preferably a human, includes administering to a mammal a compound of formula (I): 

Pyridazine derivatives and their use as inhibitors of stearoyl-CoA desaturase-1 activity in a mammal

This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, RR, R, R, R, R, R, R, and Rare as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.

Heterocyclic compounds suitable for the treatment of diseases related to elevated lipid levels

Piperazine derivatives as stearoyl-coa desaturase inhibitors and their use as therapeutic agents

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): Formula (I) where x, y, G, J, L, M, V, W, R, R, R, R, R, R, R, R, R, R, and Rare defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase

Growing community of inventors

Coquitlam, Canada

Shifeng Liu