Tokitae LLC

University of Washington

Tokitac LLC

Shieng Liu

Nels R Peterson

Fong-Li Chou

Lowell L Wood, Jr

Lawrence Morgan Fowler

Philip Andrew Eckhoff

Fridrik Larusson

Clarence T Tegreene

David J Yager

Nathan P Myhrvold

William Henry Gates, Iii

David Joseph Gasperino

Jennifer Ezu Hu

Peter K Maier-Laxhuber

Ozgur Emek Yildirim

Ralf W Schmidt

Reiner M Wörz

Daniel M Ratner

Jae-Hyun Chung

Brian L Pal

Ryan Calderon

Kyong-Hoon Lee

Dayong Gao

Jeffrey W Chamberlain

Krishnan Natarajan

Fong Li Chou

Woonhong Yeo

Gareth Fotouhi

Kie Seok Oh

Roderick A Hyde

Edward K Y Jung

Muriel Y Ishikawa

Victoria Y H Wood

Charles Whitmer

Nathan John Pegram

Michael Friend

David Keith Piech

Maurizio Vecchione

Shannon Weise Stone

Roderick T Hinman

Jonathan Bloedow

Philip A Welkhoff

Ivan Poleshchuk

Matthew W Peters

Matthew F Rosen

John Boomgard

William Gates

Philip Andrew Welkhoff

Reinier M WÖRZ

In some embodiments, an affixed group of pharmaceutical vials with frangible connectors includes: a plurality of pharmaceutical vials arranged as a group of pharmaceutical vials, each of the plurality of pharmaceutical vials shaped and positioned to minimize a total volume of the group of pharmaceutical vials, each of the pharmaceutical vials including at least one external side with a surface configured to reversibly mate with a corresponding external side and a surface of an adjacent pharmaceutical vial; and a plurality of frangible connectors, wherein at least one frangible connector is affixed to the surface of at least two of the plurality of pharmaceutical vials within the group of pharmaceutical vials, and at least one frangible connector is affixed to each of the plurality of pharmaceutical vials.

Affixed groups of pharmaceutical vials including frangible connectors

Portage storage containers including controlled evaporative cooling systems are described herein. In some embodiments, a portable container including an integral controlled evaporative cooling system includes: a storage region, an evaporative region adjacent to the storage region, a desiccant region adjacent to the outside of the container, and an insulation region positioned between the evaporative region and the desiccant region. A vapor conduit with an attached vapor control unit has a first end within the evaporative region and a second end within the desiccant region. In some embodiments, the controlled evaporative cooling systems are positioned in a radial configuration within the portable container.

Temperature-controlled portable cooling units

Pacifier devices with internal reservoirs and metering units are described. The metering units provide single dosages of an internal supplement material during a fixed period of time. For example, embodiments of pacifier devices can be utilized to provide supplemental nutrition paste or gel to undernourished infants with metered dosages as appropriate to the supplement.

Pacifier device for metered dosing of supplements to infants

Generally, this disclosure relates to methods of prioritizing or directing available power to a main device, such as a temperature-stabilized and/or temperature-controlled storage container. In an embodiment, the method may include measuring electrical power available from a solar photovoltaic module array that is electrically coupled to the main device, and modulating the electrical power drawn by the main device based on the available electrical power. Available power unused by the main device may be diverted to one or more secondary devices.

Directing or modulating electrical power drawn by one or more loads from a solar photovoltaic module array while maintaining a buffer margin

A refrigeration device includes a thermal transfer unit with an evaporative region, an adiabatic region, and a condensing region with a reversible valve attached to the adiabatic region. The device includes a container sealed around PCM, with a set of refrigeration coils of a compressor unit in thermal contact with the PCM. A storage region is in thermal contact with the evaporative region of the thermal transfer unit. A controller is operably connected to the reversible valve and the refrigeration compressor unit. The storage region can be used to store cold packs within a predetermined temperature range for medical outreach.

Devices for use with refrigeration devices including temperature-controlled container systems

Multi-monodose containers are described including a row of at least two vials, a first vial connected to an adjacent second vial through an articulating joint, the articulating joint sufficiently flexible to reversibly mate a planar outer surface of the first vial with a planar outer surface of the adjacent second vial; wherein the row of the at least two vials is configured to form a first rectangular packing cross-sectional area in an expanded configuration and configured to form a second rectangular packing cross-sectional area in a folded configuration, the second rectangular packing cross-sectional area smaller than the first rectangular packing cross-sectional area.

Multi-monodose containers

Disclosed embodiments include portable devices for cold chain storage and methods of fabricating portable devices for cold chain storage. In an illustrative embodiment, a portable device for cold chain storage includes a container defining therein a storage region. The container includes an inner cylinder, and the storage region is defined coaxially inwardly of the inner cylinder. The inner cylinder includes phase change material disposed therein, and the phase change material is in thermal communication with the storage region. The inner cylinder also includes evaporative coils disposed therein. The evaporative coils are embedded in the phase change material. The container also includes a thermally insulated outer cylinder. An outer wall of the outer cylinder is disposed radially outwardly of an outer wall of the inner cylinder.

Portable device for cold chain storage

Methods are described for packaging a foldable container including covering a multi-monodose container in an expanded configuration with a hermetically-sealable overwrap, the multi-monodose container including a row of interconnected monodose pharmaceutical vials, each of the monodose pharmaceutical vials enclosing at least one pharmaceutical agent, the interconnected monodose pharmaceutical vials connected to one another by one or more articulating joints sufficiently flexible to form a folded configuration of the multi-monodose container; exerting a force on at least one of the monodose pharmaceutical vials; bending the one or more articulating joints to form the folded configuration of the multi-monodose container in response to the exerted force; and sealing the hermetically-sealable overwrap to form a hermetic seal around the folded configuration of the multi-monodose container.

Method of packaging multi-monodose containers

In some embodiments, a refrigeration device includes: walls substantially forming a liquid-impermeable container configured to hold phase change material internal to the refrigeration device; at least one active refrigeration unit including a set of evaporator coils positioned at least partially within the liquid-impermeable container; a unidirectional thermal conductor with a condensing end and an evaporative end, the condensing end positioned within the liquid-impermeable container; a first aperture in the liquid-impermeable container, the first aperture of a size, shape and position to permit the set of evaporator coils to traverse the aperture; a second aperture in the liquid-impermeable container, the second aperture including an internal surface of a size, shape and position to mate with an external surface of the unidirectional thermal conductor; and one or more walls substantially forming a storage region in thermal contact with the evaporative end of the unidirectional thermal conductor.

Refrigeration devices including temperature-controlled container systems

In some embodiments, a medicinal storage container includes: a desiccant unit including external walls forming a gas-impermeable barrier around an interior desiccant region and including an aperture; a heating element; a controller operably attached to the heating element; a cooling unit; a compressor system including at least one evaporator coil unit, the compressor operably connected to the controller; a vapor conduit, the vapor conduit attached to a the desiccant unit at a first end, the vapor conduit attached to the evaporative cooling unit at a second end, the vapor conduit forming an internal, gas-impermeable passageway between the desiccant unit and the cooling unit; a vapor control unit attached to the vapor conduit and operably attached to the controller; and a medicinal storage unit including external walls encircling a medicinal storage region including a temperature sensor operably connected to the controller.

Temperature-controlled medicinal storage devices

In some embodiments, a refrigeration device includes: walls substantially forming a liquid-impermeable container configured to hold phase change material internal to a refrigeration device; at least one active refrigeration unit including a set of evaporator coils positioned within an interior of the liquid-impermeable container; walls substantially forming a storage region; and a heat transfer system including a first group of vapor-impermeable structures with a hollow interior connected to form a condenser in thermal contact with the walls substantially forming a liquid-impermeable container, a second group of vapor-impermeable structures with a hollow interior connected to form an evaporator in thermal contact with the walls substantially forming a storage region, and a connector with a hollow interior affixed to both the condenser and the evaporator, the connector forming a liquid and vapor flow path between the hollow interior of the condenser and the hollow interior of the evaporator.

Methods and systems are provided for concentrating particles (e.g., bacteria, viruses, cells, and nucleic acids) suspended in a liquid. Electric-field-induced forces urge the particles towards a first electrode immersed in the liquid. When the particles are in close proximity to (e.g., in contact with) the first electrode, the electrode is withdrawn from the liquid and capillary forces formed between the withdrawing electrode and the surface of the liquid immobilize the particles on the electrode. Upon withdrawal of the electrode from the liquid, the portion of the electrode previously immersed in the liquid has particles immobilized on its surface.

Particle concentration system

In some embodiments, a regulated thermal transfer device for a storage container includes: a phase change material unit, the phase change material unit including one or more walls surrounding a phase-change material region, and an aperture in the one or more walls; a heat pipe with a first end positioned within the phase change material unit, and a second end; a thermoelectric unit thermally connected to the second end of the heat pipe; a heat sink connected to the thermoelectric unit, and positioned to radiate heat away from the thermoelectric unit; and an electronic controller operably connected to the thermoelectric unit; wherein the regulated thermal transfer device is of a size and shape to be positioned so that the phase change material unit is within a storage region of a temperature-stabilized storage container, and the thermoelectric unit is positioned adjacent to an external surface of the temperature-stabilized storage container.

Temperature-stabilized storage systems with integral regulated cooling

Growing community of inventors

Bellevue, WA, United States of America

Shieng Liu