Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd.

Medshine Discovery Inc.

Shicong Wang

Tingting Yin

Juan Yu

Fei Hong

Jian Li

Shuhui Chen

Haiying He

Zhigan Jiang

Zhifei Fu

Miaorong Luo

Jinming Huang

Zhiliang Chen

Xiaoping Zheng

Jinxiang Zeng

Longhui Gao

Huijun Yuan

Kaili Jian

A crystal form of a pyrazin-2(1H)-one compound and a preparation method therefor. The present invention specifically related to a compound of formula (II) and a preparation method for a crystal form of the compound. 

Crystal forms C and E of pyrazin-2(1H)-one compound and preparation method therefor

Disclosed are a crystal form of a thieno[2,3-c]pyridazine-4(1H)-one compound, a preparation method therefor and the use thereof in the preparation of a drug as an inhibitor of ACC1 and ACC2. 

Crystal form of thieno[2,3-c]pyridazine-4(1H)-one compound, preparation method therefor and use thereof

Disclosed is a total flavonoids extract ofKitam., containing 80%-85% of rutin by weight percent content. The results of pharmacological experiments show that the extract can lower the activity of xanthine oxidase in the liver of a hyperuricemia model mouse and reduce the synthesis of uric acid to a certain degree and has a certain uric acid-lowering effect, and can be used as a potential drug for treating hyperuricemia or gout. The method for preparing the total flavonoids extract ofKitam. comprises: after an extraction step, selecting a complex enzyme composed of enzymes with a specific composition and a specific ratio for enzymolosis, and further carrying out the step of extracting and concentrating with macroporous resin and isolating and purifying with macroporous resin, so that the HPLC purity of rutin in the resulting total flavonoids extract ofKitam. reaches 80%-85%.

Total flavonoids extract ofKitam., preparation method therefor and use thereof for treating hyperuricemia

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Zhangzhou, China

Shicong Wang