Jiangsu Simcere Pharmaceutical R&d Co., Ltd

Jiangsu Simcere Pharmaceutical Co., Ltd

Jiangsu Simovay Pharmaceutical Co., Ltd.

Yantai Yenepharma Co., Ltd.

Shibao Yang

Jian He

Lei Wang

Peng Wang

Xiaoqiang Li

Fang Fang

Rong Chen

Xin Huang

Anyuan Zhang

Xiaojin Yin

Zheng Jiang

Zhengping Zhang

Lin Feng

Qingli Dong

Zhaolong Gong

Fulong Li

Yao Hua

The present invention relates to the use of a composition for preparing a medicament for the treatment of amyotrophic lateral sclerosis and associated disorders. The composition comprises 3-methyl-1-phenyl-2-pyrazoline-5-one or pharmaceutically acceptable salts thereof and borneol. The medicament is a drug used for delaying the occurrence time of amyotrophic lateral sclerosis and extending the survival time, and for improving memory function defect of amyotrophic lateral sclerosis.

Use of composition for preparing a medicament for treatment of amyotrophic lateral sclerosis

Disclosed are 1,4-dihydro-naphthyridine derivatives and pharmaceutical composition and uses thereof. The 1,4-dihydro-naphthyridine derivatives are a compound capable of inhibiting acetylcholinesterase activity and preventing extracellular calcium from flowing into a cell via a calcium channel, i.e., having a dual-activity, which are of potential importance as a pharmaceutical and can be used to prepare the drugs for treating cardiovascular diseases, cerebrovascular diseases and dementia.

1,4-dihydro-naphthyridine derivative and pharmaceutical composition and use thereof

A pharmaceutical composition comprises 3-methyl-1-phenyl-2-pyrazolin-5-one and borneol, and can be used to prepare the medicine for treating cerebrovascular diseases.

Pharmaceutical composition and its use in the preparation of a medicament for the treatment of cerebrovascular diseases

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Nanjing, China

Shibao Yang