The University of Texas System

Shiaw-Yih Lin

Gordon B Mills

Daniel McGrail

Chun-Jen Lin

Eric Jonasch

Patrick Pilie

Guang Peng

Curtis Chun-Jen Lin

Methods for increasing immune therapy response and predicting likelihood of cancer metastasis by analyzing the expression of genes associated with replication stress response. In some aspects, cancers are treated with immune checkpoint inhibitors and/or MEK inhibitors. Methods for selecting patients by analyzing the expression of genes associated with a defect in replication stress response are also provided.

Replication stress response biomarkers for immunotherapy response

Methods for identifying and treating cancers that are DNA repair, such as homologous recombination (HR) repair, defective or sensitive to PARP inhibitors or platinum-based therapy. In some aspects, DNA repair, such as HR repair, defective cancers are treated with a PARP inhibitor therapy or cisplatin. Methods for sensitizing cancers to a PARP inhibitor therapy are also provided.

Gene signatures to predict drug response in cancer

Methods for identifying and treating cancers that are homologous recombination (HR)-repair defective. In some aspects, HR defective cancers are treated with a PARP inhibitor therapy. Methods for sensitizing cancers to a PARP inhibitor therapy are also provided.

Gene signature to predict homologous recombination (HR) deficient cancer

Growing community of inventors

Pearland, TX, United States of America

Shiaw-Yih Lin