Development Center for Biotechnology

Shian-Yi Chiou

Chu-Bin Liao

Shih-Chieh Yen

Po-Ting Chen

Hui-Chen Wang

Hung-Kai Chen

Shao-Zheng Peng

Yu-Chih Pan

Chen-Hsuan Ho

Tsung-Hui Li

Hung-Jyun Huang

Bo-Rong Chen

Disclosed are compounds of formula (I) below and tautomers, stereoisomers, isotopologues, or pharmaceutically acceptable salts thereof: in which each of variables R, ring A, L, W, V, and G is defined herein. Also disclosed are a method for treating disease or disorder mediated by Tyro3, Axl, and/or Mer kinase with a compound of formula (I) or a tautomer, stereoisomer, isotopologue, or salt thereof and a pharmaceutical composition containing same.

Heterocycle compounds as Tyro3, Axl and MerTK (TAM) family of receptor tyrosine kinase inhibitors

A compound, capable of inhibiting kinases, for the treatments of diseases or disorders mediated by such kinases, has a structure of formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt thereof. The compound can be used in the treatments of diseases or conditions mediated by CSF-1R, c-KIT, FLT3, or PDGFR kinases. Such diseases or conditions may include cancers, autoimmune diseases, and bone resorptive diseases.

Quinoxaline compounds as type III receptor tyrosine kinase inhibitors

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Taipei, Taiwan

Shian-Yi Chiou