Amylin Pharmaceuticals, Inc.

Ilypsa, Inc.

Gryphon Therapeutics, Inc.

Shiah-yun Chen

Stephen B H Kent

Paolo Botti

Christie L Hunter

Gerd G Kochendoerfer

James A Bradburne

Sonya Cressman

Donald W Low

Dominique Charmot

Han-Ting Chang

Tomasz W Glinka

Jerry M Buysse

Michael James Cope

Jun Shao

Elizabeth Goka

Damien Cartigny

Jill G Wilken

Gerd Kochendoerfer

Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.

Multivalent indole compounds and use thereof as phospholipase-A2 inhibitors

The present invention relates to methods and compositions for modifying peptides, polypeptides and proteins with polymers, especially glyco-mimetic polymers, so as to improve their biological activity or pharmacokinetic properties. The invention further provides methods and uses for such polymer-modified peptides, polypeptides and proteins. The invention is particularly suitable for use in the synthesis of polymer-modified synthetic bioactive proteins (FIG.D), and of pharmaceutical compositions that contain such proteins.

Polymer-modified synthetic proteins

The present invention concerns methods and compositions for extending the technique of native chemical ligation of a wider range of peptides, polypeptides, other polymers and other molecules via an amide bond (see FIG.). The invention further provides methods and uses for such proteins and derivatized proteins. The invention is particularly suitable for use in the synthesis of optionally polymer-modified, synthetic bioactive proteins, and of pharmaceutical compositions that contain such proteins.

Pseudo native chemical ligation

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Mountain View, CA, United States of America

Shiah-yun Chen