University of Rochester

Shey-Shing Sheu

Marion W Anders

Richard L Parton

Mark Frederick Bocko

Arthur Jay Moss

Jalil Shojaie

Ilan Goldenberg

Leif Olson

Ido Goldenberg

Paul Spencer Brookes

Lin Xu

Virendra K Sharma

Gisela Beutner

James L Robotham

There is provided a medical device comprising a low intensity electromagnetic field source to increase the respiratory control index values (RCI) of mitochondria. The medical device may be implantable, such as a cardiac rhythm management device, a stent, or a vascular graft. The device may also be worn externally, such as a treatment device having a matrix of magnetic coils that is worn on the head for the treatment of various neurological conditions.

Low intensity magnetic field devices for treatment of cardiac and neurological disorders

The present invention is a mitochondria-targeted antioxidant prodrug useful for the prevention or treatment of diseases or conditions associated with mitochondrial dysfunction resulting from changes in the mitochondrial redox environment. Antioxidant prodrugs of the invention are produced by modifying an antioxidant to a fatty acid so that the resulting prodrug is targeted to and activated by an enzyme of mitochondrial fatty acid beta-oxidation.

Mitochondria-targeted antioxidant prodrugs and methods of use

Disclosed are hydrophilic choline/N-heterocycle ester compounds containing single amino acids, peptides, or derivatives thereof which have the potential to express anti-oxidant activity capable of reducing reactive oxygen species in cells. These compounds may be used to inhibit oxidative stress-induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.

Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof

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Pittsford, NY, United States of America

Shey-Shing Sheu