Transform Pharmaceuticals, Inc.

Sherry Morissette

Orn Almarsson

Matthew Lynn Peterson

Michael MacPhee

Julius F Remenar

Jules Remenar

Stephen Soukasene

The invention provides novel soluble conazole crystalline forms (e.g. itraconazole, posaconazole and saperconazole) that include salts, co-crystals and related solvates useful as pharmaceuticals. The invention also provides pharmaceutical compositions comprising, and processes for making, these conazole crystalline forms. Methods of using such compositions for the treatment or prevention of systemic and local fungal, yeast, and dermatophyte infections are also provided.

Crystalline forms of conazoles and methods of making and using the same

Novel solvates and crystal polymorphs of Ritonavir are disclosed, as well as methods of making them. Specific solvates of the compound include a formamide solvate and a partially desolvated solvate. Also disclosed are methods of making previously known forms of Ritonavir. Methods of using the novel forms of Ritonavir for the treatment of diseases, such as HIV-infection, are disclosed, as are pharmaceutical compositions and unit dosage forms comprising the novel forms of Ritonavir.

Solvates and polymorphs of ritonavir and methods of making and using the same

CIS-itraconazole crystalline forms and related processes, pharmaceutical compositions and methods

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Arlington, MA, United States of America

Sherry Morissette