Bayer Healthcare LLC

Bayer Corporation

Sherry J Jamison

Yingping Deng

Andrew J Edelbrock

Methods and devices for performing in situ hematocrit adjustments during glucose testing using glucose-monitoring products and using those adjusted values to estimate the hematocrit value of blood samples to reduce or eliminate the assay bias caused by the different hematocrit levels of blood samples. One method involves measuring the glucose value, Glu, of the blood sample; measuring the resistance of the blood sample (R) using a biosensor reagent; measuring the resistance of plasma (R) using the biosensor reagent; determining the calculated resistance of red blood cells, R, of the blood sample according to the relationship;calculating the percent hematocrit, % Hct, of the blood sample; determining whether to adjust the glucose value, Glu, to an adjusted glucose value, Glu; and using the percent hematocrit, % Hct, and either the glucose value, Glu, or the adjusted glucose value, Glu, to adjust for any bias of the biosensor reagent.

Methods for performing hematocrit adjustment in glucose assays and devices for same

Disclosed is an improved electrochemical sensor for the detection of an analyte in a fluid test sample. The electrochemical sensor is of the type in which the fluid test sample is drawn into a capillary space and the improvement to the sensor involves an arrangement where a portion of the sensor's counter electrode is placed on the edge of the capillary space in a relationship to the sensor's working electrode such that if the capillary space is not completely filled there will be generated only a very weak current. When the sensor is connected to a properly programmed current detector, the weak current caused by the underfilling of the capillary space will be detected as an error and will notify the user of the sensor that the test should not be continued.

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Goshen, IN, United States of America

Sherry J Jamison