Zymogenetics, Inc.

Sherri L Mudri

Janine M Bilsborough

Eric Chadwick

Stephen R Jaspers

Use of IL-31 agonists, including IL-31, are used to treat agonists are used to treat asthma, airway hyper-responsiveness or allergic rhinitis. The method comprise inhibiting, reducing, limiting or minimizing production of proinflammatory cytokines and include administration of the IL-31 agonist during sensitization or challenge resulting in the asthma, airway hyper-responsiveness or allergic rhinitis state.

Methods of using IL-31 to treat chronic obstructive pulmonary disease (COPD)

Methods of determining dose of IL-31 agonist to treat pulmonary inflammation

Use of IL-31 agonists, including IL-31, are used to treat agonists are used to treat asthma, airway hyper-responsiveness or allergic rhinitis. The method comprise inhibiting, reducing, limiting or minimizing production of proimflammatory cytokines and include administration of the IL-31 agonsit during sensitization or challenge resulting in the asthma, airway hyper-responsiveness or allergic rhinitis state.

Methods of using IL-31 to treat airway hyper-responsiveness and asthma

Isolated DNA molecules comprising a portion of a human hexokinase gene promoter are disclosed. The molecules comprise promoter and insulin-sensitive transcription regulatory elements. These molecules can be used within methods for detecting insulin-like activity in test substances.

Growing community of inventors

Seattle, WA, United States of America

Sherri L Mudri