Merck + Co., Inc.

Merck Sharp + Dohme Corp.

Merck Sharp & Dohme De Espana Sa

Orchid Pharma Ltd.

Agrobiologics LLC

Sheo B Singh

Deborah L Zink

Russell B Lingham

Keith C Silverman

Anne W Dombrowski

Fernando Pelaez

Gerald F Bills

Isabel Martin

Jon David Polishook

Ana M Teran

Michael A Goetz

Jun Wang

Joyce A Greene

Olga Genilloud

David Brian Olsen

Ali Shafiee

John G Ondeyka

Katherine Young

Jon D Polishook

Hiranthi Jayasuriya

Lihu Yang

Qun Dang

Robert R Wilkening

Jing Su

Dongfang Meng

George M Garrity

Takao Suzuki

James M Apgar

Mihir Mandal

Sandra J Rattray

Dan A Ostlind

Daria Hazuda

Yu L Kong

Kevin M Byrne

Dann Parker

Angela Basilio

Michael R Tota

Daria Jean Hazuda

Olga Genillourd

Manuel Sanchez

Gary K Darland

Diane M Vesey

Christine Lange Cannova

Arlene M Dahl

Ronald E Painter

Ravi P Nargund

Michael W Miller

Robert D Larsen

Shuzhi Dong

Alan D Adams

James Francis Dropinski

Robert A Giacobbe

Leeyuan Huang

A Brian Jones

Francisca Vicente

Claude Dufresne

Jack L Smith

Chris H Senanayake

Hongwu Wang

Mary N Omstead

Gopalan Balasubramanian

Brian Heimbuch

Magda M Gagliardi

Venkatesan Parameswaran

Maria S Meinz

Clare E Gutteridge

Maneesh Paul-Satyaseela

E Tracy Turner Jones

Hariharan Periasamy

Siobhan Stevens-Miles

Ignacio P Gonzalez

Sridhar Ramanathan Iyer

Oscar Salazar

Timothy Bill

Pilar Hernandez

Thomas R Vernhoeven

Jose Rueben Tormo

Lucia Herranz

Gerard F Bills

Josep Guarro

Barry A Katz

Carmen Cascales

Mary Nallin-Omstead

Aileen Bouffard

Daniel P Ring

Weiguo Lui

Bharani Thirunavukkarasu

Ali Shiafee

Jeffrey C Hastings

Prabhakar Rao Gunturu

Ziqiang Guan

Manjula Devi Deshkumar

Scott Knoble Smith

Chidambaram Venkateswaran Srinivasan

Venkateshwarlu Jakkala

Peter J Felock

Ignacio Gonzalez

Michael Miller

This invention relates to carbapenem compounds of the following formula: wherein A, Z, X, R, and Rare as described herein, as well as stereoisomers, pharmaceutically acceptable salts or N-oxides thereof, which may be useful for the treatment of bacterial infections, particularly drug-resistant bacterial infections, as well as the processes for the preparation of compounds, the pharmaceutical compositions of these compounds and their use in the treatment of bacterial infection.

Substituted carbapenems for the treatment of bacterial infections

The present invention is concerned with the use of the natural product Ilicicolin H as an agricultural fungicide, compositions comprising Ilicicolin H, and the use of such compositions to treat, control or prevent fungal infection in agricultural products.

Use of the antifungal ilicicolin H in agriculture

The present invention relates to novel nargenicin related compounds which can inhibit DnaE and have antibacterial, particularly antimycobacterial activity against. The present invention also relates to method for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections byby administering an antimycobacterially effective amount of nargenicin or a nargenicin-related compound and/or their pharmaceutically acceptable salts.

Nargenicin compounds and uses thereof as antibacterial agents

The present invention relates to novel compounds of formulae (I) and (II) and pharmaceutically acceptable salts thereof that are useful in the treatment and/or prevention of human and animal bacterial infections and associated diseases and conditions; compositions containing such compounds; derivation of such compounds by fermentation and isolation, partial synthesis and total synthesis; methods of inhibiting bacterial growth; methods of treating, preventing or controlling bacterial infection; biologically pure cultures of bacterial strains from which such compounds may be produced; and processes for preparing compositions containing such compounds. 

Extracts from kibdelos porangium as antibacterial agents

The present invention relates to natural products that possess fatty acid synthesis inhibitor activity and can be used to treat and prevent diseases such as obesity, cancer, diabetes, fungal infections,infections, malarial infections and other apicomplexan protozoal diseases.

Method of treatment using fatty acid synthesis inhibitors

The present invention relates to natural products that possess fatty acid synthesis inhibitor activity and can be used to treat and prevent diseases such as obesity, cancer, diabetes, fungal infections, Mycobacterium tuberculosis infections, malarial infections and other apicomplexan protozoal diseases.

Fermentation of a nutrient medium with a eubacteriumsp. yields a novel antibacterial compound of structural formula (I). 

Antibiotic compound

Fermentation of a nutrient medium with a eubacteriumsp. yields a novel antibacterial compound of structure (I). 

Antibiotic compounds

Compounds of Formula Iand the pharmaceutically acceptable salts and esters thereof, wherein Z is selected from the group consisting of:

Therapeutic compounds for treating dyslipidemic conditions

Compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines are described. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. The culture Cytospora sp. MF 6608 (ATCC PTA-1691) is also disclosed, as well as processes for making a compound of the present invention employing the culture.

HIV integrase inhibitors

Natural products such as certain chaetochromins are described. These compounds are useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

Compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines are described. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. The culture Actinoplanes sp. MA7220 (ATCC 202188) is also disclosed, as well as processes for making compounds of the present invention employing the culture.

Novel tetracyclic aromatic ketones are natural product compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. Further, the novel fungal cultures MF6388 (ATCC 74478), Sterile Fungus, and MF6591 (ATCC 74477), Ascochyta sp. are also disclosed. Further, the cultures Sterile Fungus MF6388 (ATCC 74478) and Ascochyta sp. MF6591 (ATCC 74477) are also disclosed, as well as processes for making compounds of the present invention employing the cultures.

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Edison, NJ, United States of America

Sheo B Singh