Arizona State University

Shengxi Chen

Sidney M Hecht

Yanmin Zhang

Xiaoguang Bai

Larisa Dedkova

Provided herein are therapeutic agents having specificity for having inhibitory activity against cancer cells that overexpress human epidermal growth factor receptor (HER) genes, including therapeutic agents comprising one or more HER-targeting peptides, pharmaceutical compositions comprising such therapeutic agents, and methods of using such compositions to treat or prevent a cancer or other disease condition associated with HER overexpression.

DNA-affibody-drug nanoparticles for inhibiting the metastasis of cancer cells overexpressing HER2

Compositions and methods relating to bacterial ribosomes selected to increase the incorporation of at least one glycosylated amino acid into a protein versus a wild-type bacterial ribosome. Selection embodiments include growing bacteria in the presence of a puromycin derivative, wherein a surviving clone has a ribosome that incorporates at least one glycosylated amino acid into a protein.

Engineered bacterial ribosome compositions and methods

A method to enhance a male erection or female arousal in a mammal includes topically administering a compound of Formula 1 to the mammal.

Skin-like condoms having active ingredients to enhance a male erection and a female arousal

A condom apparatus including at least one of a condom containing a compound of Formula 1 wherein the condom is configured to deliver one or more active ingredients selected from the group consisting of arginine, a vasodilator, nitrates, an ergot alkaloid, a long acting alpha-adrenoceptor blocker, a short acting alpha-adrenoceptor blocker, an anti-hypertensive, a prostaglandin, and a phosphodiesterase inhibitor is disclosed.

The present disclosure provides a low cost, high sensitivity, high specificity and rapid diagnostic apparatus and method to detect nucleic acids in a sample at room temperature. As low as tens of copies of nucleic acids can be detected without any additional equipment.

Apparatuses and methods for detecting nucleic acids

A condom assembly includes at least one of a condom, patch or glove made of at least one of natural latex, synthetic latex or the mixture of natural latex and synthetic latex. The natural latex, synthetic latex or the mixture of natural latex and synthetic latex contain prodrugs of nitric oxide and/or other active ingredients.

A series of double-component, bis O-aryl diazeniumdiolate derivatives are provided, of which each molecule can release up to four nitric oxide molecules. These compounds show cytotoxic activities to cancer cells, such as human leukemia, breast cancer and lung cancer. Among them, the compound 3 showed the highest specific activity against human leukemia cells.

Bis-diazeniumdiolate compounds as anti-cancer agents

Peptide-DNA chimeras for treatment of HER overexpressing cancers

The present disclosure relates to novel fusion proteins that bind to the HIV-1 gp120 antigen. The present disclosure also relates to nucleic acids, plasmids and host cells that comprise a sequence that encodes the fusion proteins of the disclosure. The fusion proteins of the disclosure can be used in applications to detect the presence of HIV-1 gp120 protein, to detect an HIV-1 infection and to monitor treatment of an HIV-1 infection.

Growing community of inventors

Chandler, AZ, United States of America

Shengxi Chen