Nanjing Luyesike Pharmaceutical Co., Ltd.

Jiangsu Provincial Institute of Materia Medica Co., Ltd.

Wuxi Mtlh Biotechnology Co., Ltd.

Shengtao Yuan

Hua Zhou

Lan Huang

Guang Cheng

Aihua Zhang

Yipeng Shen

Ancheng Ji

This present invention discloses a heterocyclic substituted acardite derivate and application thereof, namely compounds in the general formula (1) or the general formula (2) or pharmaceutically acceptable salts thereof, wherein A is monosubstituted or polysubstituted quinoline, isoquinoline, quinazoline, pyrrole or pyrimidine, and the substituent is halogen, Calkyl, Chaloalkyl, Calkoxy, Chaloalkoxy, Calkylamino, Chaloalkylamino, amino or nitryl; Ris Calkyl; Ris one or more selected from hydrogen, halogen, alkyl, alkoxy, haloalkyl or haloalkoxy; and Ris one or more selected from hydrogen, halogen, alkyl, alkoxy, haloalkyl or haloalkoxy. The compound of the present invention and the pharmaceutically acceptable salt thereof can be used for treating tumor or leukemia. 

Heterocyclic substituted acardite derivate and application thereof

Provided is the composition of a peptide and its mutagenic version, or other derivatives with the same 3-D structure with activity to bind the extracellular domain of PDGFR-&#x3b1;, or -&#x3b2;, but does not dimerize by itself, wherein said peptide comprises the sequence shown as SEQ ID NO: 1, 2 or 3. Also provided is the composition of the nucleotide sequence encoding said peptide and its derivatives, and the usage of said peptide and derivatives of the peptide in preparation of medicine for the prevention and treatment of fibrosis diseases, such as liver, kidney, and lung fibrosis, primary cancer, and cancer metastasis, especially stomach cancer, liver cancer, breast cancer, and lung cancer.

Pharmaceutical being used for treating cancer and fibrosis disease and the composition and uses thereof

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Jiangsu, China

Shengtao Yuan