Sunshine Lake Pharma Co., Ltd.

North & South Brother Pharmacy Investment Company Limited

Shengqiang Pan

Yingjun Zhang

Xiaojun Wang

Xinye Yang

Junwen Wu

Changchung Cheng

Rui Guo

Shengtian Cao

Shaohui Xiong

A nitrogen-containing tricyclic compound which acts as modulator of FXR, or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and the use of the compound for the treatment of disease and/or condition mediated by FXR are described. And a pharmaceutical composition containing the compound disclosed herein and a method of treatment of disease and/or condition mediated by FXR comprising administering the compound or the pharmaceutical composition thereof are also described.

Nitrogen-containing tricyclic compounds and uses thereof in medicine

The present invention relates to novel tricyclic compounds which can bind to FXR and act as modulators of the FXR, or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and the uses of the compounds for the treatment of diseases and/or conditions mediated by FXR. The invention further provides a pharmaceutical composition containing the compound disclosed herein and a method of treatment of diseases and/or conditions mediated by FXR comprising administering the compound or the pharmaceutical composition.

Tricyclic compounds and uses thereof in medicine

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Dongguan, China

Shengqiang Pan