Guangzhou Eggbio Co., Ltd.

Shengjiang He

Ke Ding

Zhengchao Tu

Xiaoyun Lu

Yuanyuan Cao

Tianyu Zhang

Junting Wan

Jian Tang

Xiantao Zhang

Tian Wu

Disclosed in the disclosure are a pyrazolo [1,5-a] pyrideine compound with structural features as shown in formula (I) or a pharmaceutically acceptable salt, stereoisomer or prodrug molecule thereof and a use thereof. Such compounds have a good in vitro antituberculosis activity, and the minimal inhibitory concentration (MIC) of the compounds is lower than 0.1 &#x3bc;g/mL and partially achieves 0.01 &#x3bc;g/mL, and have a very strong inhibiting effect on clinically selected multi-drug resistant tuberculosis (MDR-TB) strains. In an in vivo experiment, the pyrazolo[1,5-a] pyrideine compounds of the present disclosure can effectively scavenge the infectious dose of H37Ra in a mouse body at 20 mg/kg/d does, thereby being a new type of antituberculosis compound. 

Pyrazolo[1,5-A]pyridine compounds and use thereof

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Guangzhou, China

Shengjiang He