Bio-thera Solutions, Ltd., Co.

Other

Cor Therapeutics, Inc.

Abmaxis, Inc.

Bio-thera Solutions, Ltd.

Humab Solutions, Inc.

Shengfeng Li

David R Phillips

Chao Qin

Weijia Tang

Pingyu Zhong

Peizhi Luo

Xinwei Wang

Jin-Chen Yu

Caili Wang

Xiaobin Deng

Shengjiang Liu

Songnuan Tan

Xiaoyun Wu

Ziqiang Ou

Yili Yang

Chenchao Xu

Xiaoyang Huang

Xian Peng

The present invention generally relates to compounds comprising antibodies, antigen-binding fragments thereof, polypeptides, and immunoconjugates that bind to TROP2 (TACSTD2). The present invention also relates to methods of using such TROP2-binding molecules for diagnosing and treating diseases, such as malignancies.

Compounds and methods for the treatment of TROP2 positive diseases

Disclosed herein are anti-ERB B2/NEU antibodies conjugated with maytansinoid drugs for targeted delivery to disease tissues. Methods relating to the preparation and uses of such drug conjugates to treat ERB B2/NEU positive cells in cancers are provided.

Compounds and methods for the treatment of ERB B2/NEU positive diseases

Provided are bispecific antibodies having a full-size antibody portion with two light chains and two heavy chains, wherein the two heavy chains each is fused to a single-chain variable fragment (scFv) portion. In certain embodiments, the full-size antibody has specificity to EGFR and the scFv has specificity to VEGF.

Bispecific antibodies which bind EGFR and VEGF

Disclosed herein are maytansinoid drug linker derivatives which can be linked to a antigen binding unit (Abu), and maytansinoid drugs linked with an antigen binding unit (Drug-Linker-Antigen binding Unit: D-L-Abu), for targeted delivery to disease tissues. D-L-Abu, D-L-Abu derivatives, and methods relating to the use of such drug conjugates to treat antigen positive cells in cancers and immunological disorders are provided.

Maytansinoid derivatives

Disclosed herein are anti-EGFR antibodies conjugated with maytansinoid drugs for targeted delivery to disease tissues. Methods related to the preparation and uses of such antibody drug conjugates to treat EGFR positive cells in cancers are provided.

Compounds and methods for the treatment of EGFR positive diseases

The present invention provides improved tPA variants having significantly reduced susceptibility to inhibition and increased affinity for platelet integrin as compared with the wild-type tPA. The present invention also provides compositions comprising the tPA variants and polynucleotides, vectors, and host cells for producing the same as well as methods of using these tPA variants to treat disease conditions, e.g., thrombotic disorders.

Bifunctional variants of recombinant tissue-type plasminogen activator with platelet aggregation inhibitory activity

The present invention provides a technique for specific assembly of monomeric polypeptides to form a heteromultimer. This technique is particularly useful for generating a genetically diverse repertoire of heteromultimers such as antigen-binding units. The invention also provides both non-single-chain and single-chain antigen-binding units that are assembled by the technique described herein. The present invention also provides recombinant polynucleotides, vectors, host cells, and kits for producing the subject antigen-binding units. Further provided by the invention are methods of using the subject antigen-binding units.

Compositions and methods for generating chimeric heteromultimers

The present invention provides non-single-chain antigen-binding units that is stabilized by leucine zipper sequences. The experimental design is particularly useful for generating and screening for Nsc Abus that remain the binding capabilities to their respective antigens within a cell. The present invention also provides recombinant polynucleotides, host cells and kits comprising the vectors. Further provided by the invention are methods of using the subject vectors.

Compositions and methods for generating antigen-binding units

The present invention provides the amino acid and nucleotide sequence of a protein that binds to &bgr;3 integrins, &agr;IIb and Src kinase and is involved in integrin mediated signaling. Based on this disclosure, the present invention provides methods for identifying agents that block integrin mediated signaling, methods of using agents that block integrin mediated signaling to modulate biological and pathological processes, and agents that block integrin mediated signaling.

Methods of identifying agents that block the interaction of a BAP protein with a signaling partner

Nucleic acid molecules encoding Bap-1 proteins

The present invention provides the amino acid and nucleotide sequence of a protein that binds to .beta.3 integrins, .alpha.IIb and Src kinase and is involved in integrin mediated signaling. Based on this disclosure, the present invention provides methods for identifying agents that block integrin mediated signaling, methods of using agents that block integrin mediated signaling to modulate biological and pathological processes, and agents that block integrin mediated signaling.

Growing community of inventors

Belmont, CA, United States of America

Shengfeng Li