Atomic Energy Council-institute of Nuclear Energy Research

Sheng-Lun Lin

Cheng-Fang Hsu

Yu Lung Chang

Show-Wen Liu

Tsung-Hsien Chiang

Chih-Yuan Lin

A radiotracer precursor for imaging of hypoxic tissues, a radiotracer and a method for preparing the same are revealed. The radiotracer precursor, DANI, includes a nitroimidazole functional group with a feature of retention in hypoxic tissues and a bifunctional ligand able to complex with radioisotopes. Thus DANI can be used to produce radiotracers stayed in hypoxic tissues and the radiotracers are applied to medical imaging of malignant tumor with hypoxic layer.

Radiotracer precursor for imaging of hypoxic tissue, radiotracer, and method for preparing the same

The present invention relates to a radiotracer precursor for imaging of hypoxic tissues, a radiotracer and a method for preparing the same. The radiotracer precursor, BANI, includes a nitroimidazole functional group with a feature of retention in hypoxic tissues and a bifunctional ligand able to complex with radioisotopes. Thus BANI can be used to produce radiotracers retained in hypoxic tissues and the radiotracers are applied to medical imaging of malignant tumor with hypoxic layer.

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Taoyuan County, Taiwan

Sheng-Lun Lin