National Science Council

Sheng-Chih Chen

Sheng-Chu Kuo

Jin-Bin Wu

Jih-Pyang Wang

Che-Ming Teng

Che-Hing Teng

Disclosed are methods of providing antiinflammatory activity and inhibiting allergic reaction by administering Abruquinones A, B, D, E, or F to a subject in need thereof.

Abruquinone derivatives useful in the treatment of inflammation and

Disclosed are methods of isolation and purification of active constituents from Hsian-ssu-tsu (Abrus precatorius L.), and the therapeutical applications of the purified compounds. From the cloroform fraction of the methanolic extract of the roots of Abrus precatorius L., Abruquinones A, B, D, E, F, which are shown as Compounds I through V, respectively, as follows: ##STR1## were isolated and identified Pharmacological evaluations showed that these compounds possess an activity to inhibit platelet aggregation, as well as antiinflammatory, and antiallergic activities.

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Taichung, Taiwan

Sheng-Chih Chen