City University of Hong Kong

The Medical College of Wisconsin, Inc.

Sheng Chen

Joseph T Barbieri

Chen Xu

Hongyuhang Ni

Bill Kwan-wai Chan

A drug composition contains an effective amount of a drug active containing a polymyxin, an effective amount of otilonium bromide, and a pharmaceutically-acceptable carrier. A method for treating or protecting against a Gram-negative infection containing the step of administering a drug composition, a disinfecting composition similar to the drug composition, and an adjuvant for a drug active also may contain otilonium bromide.

Drug composition, method for treating infection, disinfecting composition, and drug adjuvant

Methods of using rifampicin and zidovudine and pharmaceutical compositions comprising the same to inhibit growth of and/or kill, such as antibiotic-resistant

Methods and compositions for treating carbapenem-resistant klebsiella pneumoniae infections

The present invention provides a novel modified BoNT/E catalytic domain and methods of use thereof. In one embodiment, the light chain residue 224, or a residue corresponding to residue 224, of the modified BoNT/E catalytic domain has been altered to be aspartic acid or glutamic acid. The modified catalytic domain cleaves SNAP23 but does not cleave SNAP29 or SNAP47, providing novel methods of treating diseases including without limitation, asthma, CF, chronic obstructive pulmonary, gastric acid efflux and inflammation, immune disorders with a cytokine component or cancers with a cytokine component.

Growing community of inventors

Hong Kong, China

Sheng Chen