National Science Council

Kaohsiung Medical University

Shen-Jeu Won

Chun-Nan Lin

Shorong-Shii Liou

Shyh-Chyun Yang

Bai-Luh Wei

A-Mei Huang

Hsiao-Sheng Liu

Huang-Yao Tu

Tzyh-Chyuan Hour

Yeong-Shiau Pu

Hsiao-Sheng Lieu

Kim-Hong Gan

Several ursolic acid derivatives and pharmaceutical compositions thereof are provided. The ursolic acid derivatives and the pharmaceutical compositions thereof have at least one of an anticancer and an anti-inflammatory effects. A method for increasing a reactive oxygen species in a cell is also provided. The method comprises a step of providing the cell with a pharmaceutical composition including an ursolic acid derivative.

Ursolic acid derivative and pharmaceutical composition thereof

Compounds of general Formula I in which the substituents of R.sub.1 -R.sub.7 are hydrogen, hydroxy group, C.sub.1-6 alkyl group, C.sub.1-6 alkoxy group, or epoxypropoxy, but at the most, six of the substituents can simultaneously be hydrogen, methoxy group, or hydroxy group, or epoxypropoxy group for activity against hepatoma. There are also described processes for the preparation of the novel compounds and useful intermediates. Substitute benzophenones are described.

Compounds for the treatment of hepatoma

Growing community of inventors

Tainan, Taiwan

Shen-Jeu Won