Aventis Pharma Limited

Shelley Bower

Stevan Wakefield Djuric

John R Regan

Daniel Gerard McGarry

Gregory Bernard Poli

David John Aldous

Paul Joseph Cox

Peter Charles Astles

Kevin Joseph Moriarty

Christopher Hulme

Rose Mappilakunnel Mathew

Fu-Chih Huang

This invention is directed to physiologically active compounds of formula (I) wherein represents a bicyclic ring system, of about 10 to about 13 ring members, in which the ring is an azaheterocycle, and the ring represents an azaheteroaryl ring, or an optionally halo substituted benzene ring; and N-oxides thereof, and pharmaceutically acceptable salts of the compounds of formula (I) and N-oxides thereof, Such compounds inhibit the production or physiological effects of TNF and inhibit cyclic AMP phosphodiesterase. The invention is also directed to pharmnaceutical compositions comprising compoundS of formula (I), their phatmaceUtical use and methods for their preparation.

Substituted azabicyclic compounds

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Bedminster, NJ, United States of America

Shelley Bower