Duke University

Skinceuticals, Inc.

Bio-specifics N.v.

L'oreal

Loreal Sa

L'oreal USA Creative, Inc.

Douglas Darr

Sheldon R. Pinnell

Sheldon R Pinnell

Saood Murad

Jan Zielinski

Isabelle Hansenne

Douglas J Darr

Huanshu Yang

Mostafa M Omar

An anti-aging composition containing: (a) at least one first active ingredient chosen from phloretin and its derivatives; (b) at least one second active ingredient chosen from cinnamic acid, resveratrol, retinol, ascorbic acid, tocopherol, and their derivatives; and (c) at least one non-aqueous organic solvent, with the proviso that if the composition contains ascorbic acid, water is present as a co-solvent.

Anti-aging composition containing phloretin

The present invention relates to ascorbic acid single-phase solution compositions that provide enhanced stability, enhanced solubility and an enhanced photoprotective effect as compared to prior compositions. The compositions comprise L-ascorbic acid; a cinnamic acid derivative such as p-coumaric acid, ferulic acid, caffeic acid, sinapinic acid, a derivative thereof, and a combination thereof; a solvent comprising a glycol ether and an alkanediol; and water; the composition having a pH of no more than about 3.5. The compositions may also comprise a form of Vitamin E and are useful for treatment of radical-induced damage to a subject, particularly the skin of a subject.

Stabilized ascorbic acid compositions and methods therefor

A skin-care composition containing a protective component providing protection of the skin from environmental damage and regulating natural moisture of the skin; a skin firming component; and a barrier component. Thus, the composition includes at least one component that supports the collagen structure, and at least one component that supports the body's own defense/repair mechanisms, and most preferably, at least one component that supports the skin lipid system.

Skin-care composition

A non-aqueous method of extracting olive leaves, and products formed containing the olive-leaf extract. The resulting extract is used, preferably together with vitamins C, E and A or components thereof to form a skin treatment product that has efficacy as a photoprotectant and antioxidant.

Topical composition comprising olive leaf extract

The present invention relates to the use of compositions comprising the extract of the milk thistle plant, soybean protein and alpha tocopherol, either singly or in combination, in novel compositions for topical application on skin, hair and nails. More specifically, the present invention pertains to compositions for the above use, which are suitable for the entire skin. The present invention pertains to compositions for the above use, which are characterized in that they comprise milk thistle extract, soybean protein, and alpha tocopherol, either individually or in combination.

Use of milk thistle extract in skin care compositions

Methods of inhibiting fibrosis comprising administering certain pyridoxal benzoyl hydrazones or analogs thereof are disclosed. Preferred hydrazones are pyridoxal benzoyl hydrazone, 3-hydroxyisonicotinaldehyde benzoyl hydrazone and salicylaldehyde benzoyl hydrazone. The methods are useful in treating fibrosing disorders, including dermal fibrosing disorders, fibrosis of internal organs and fibrotic conditions of the eye.

Method of inhibiting fibrosis with pyridoxal benzoyl hydrazone and

Disclosed is a method of inhibiting fibrosis in a human or animal subject afflicted with a fibrosing disorder. The method comprises administering to the subject an effective fibrosis-inhibiting amount of a compound of Formula (I): ##STR1## wherein: n is 1 or 2;

Method of inhibiting fibrosis

The present invention relates to a method of inhibiting cell proliferation and lysyl hydroxylase expression. The method involves the use of minoxidil derivatives. The inhibitory activity of hydroxy derivatives of minoxidil is such that these compounds can be used as selective antifibrotic agents.

Minoxidil analogs as inhibitors of cell proliferation and lysyl

Stable topical aqueous compositions are provided containing a concentration of L-ascorbic acid above about 1% (W/V) and maintaining a pH below about 3.5.

Stable ascorbic acid compositions

The method for preventing and for treating mammalian cicatrices such as keloids, acne scars, hypertrophic scars, wrinkles, cellulite and neoplastic fibrosis which comprises intra-dermal injection of effective amounts of a pharmacologically suitable solution of the enzymes collagenase, elastase, papain, plasminogen activator, plasmin, mast cell protease or lysosomal hydrolase, individually, and one or more of such enzymes in combination with the enzyme hyaluronidase.

Method for the prevention and treatment of scars with enzymes

A method for the prevention of and for the dissolution of mammalian cicatrices such as acne scars, keloids and other hypertrophic scars comprising intralesional injection of effective amounts of a pharmacologically suitable solution of the enzyme collagenase, by itself, and collagenase in combination with the enzyme hyaluronidase.

Growing community of inventors

Durham, NC, United States of America

Sheldon R Pinnell