University of Miami

Other

The United States of America, as Represented by the Secretary, Department of Health and Human Services

University of Southern California

University of Oregon

Pcr, Inc.

State of Oregon

Sheldon B Greer

Peter A Jones

Victor E Marquez

Jonathan Cheng

Cindy B Matsen

Eric U Selker

Chemotherapeutic and Radiation sensitizing agents which target tumor cells, specifically, based on the elevation of enzyme pathways, provide highly selective drug therapy. These agents are combined with modulating doses of cytidine deaminase inhibitors to increase selectivity. Furthermore, high doses of these cytidine deaminase inhibitors have the potential of counteracting the aggressive and metastatic characteristics of pancreatic tumors. For tumors with high levels of cytidine deaminase, such as pancreatic tumors, this elevation provides a therapeutic approach with prodrugs that require deamination for their activation. For tumors with high levels of uridine/cytidine kinase, a different class of pyrimidine analogs can be activated selectively in tumors for a therapeutic advantage.

Designer therapy of pancreatic tumors

Zebularine has hypomethylating activity, and can be used to inhibit, reverse, and/or reduce DNA methylation in vivo and in vitro. Methods are provided for treating methylation-linked conditions through the application of 2-pyrimidinone derivatives, such as Zebularine. Compositions, including pharmaceutical compositions, comprising such derivatives are also provided. Also provided are kits for use in inhibiting DNA methylation, which kits include an amount of a 2-pyrimidinone derivative.

Inhibitor of DNA methylation

A method of treating tumors with radiation is disclosed, wherein the tumor is sensitized by administering a tumor sensitizing agent comprising 5-chloro-2'-deoxycytidine, 4-N-methyl FdC and a cytidine deaminase inhibitor to a patient having the tumor. The tumor is then subjected to radiation.

Dramatic simplification of a method to treat neoplastic disease by radiation

Method and materials for sensitizing neoplastic tissue to radiation

Pharmaceutical compositions suitable for the treatment of Herpes or Herpes-like viruses are disclosed, wherein the compositions contain 5-trifluoromethyl-2'-deoxycytidine and a cytidine deaminase inhibitor. Also disclosed are methods of treating patients suffering from a disease caused by a Herpes or Herpes-like virus, with the method comprising administering to the patient a therapeutically effective amount of 5-trifluoromethyl-2'-deoxycytidine and a cytidine deaminase inhibitor.

Antiviral composition and method of treating virus diseases

Growing community of inventors

Aventura, FL, United States of America

Sheldon B Greer