Ethicon Endo-surgery, Inc.

Shelby L Cook Kornbluth

Richard William Timm

Shailendra Kumar Parihar

Jerome R Morgan

John B Schulte

Donna L Korvick

Michael D Cronin

Rebecca J Mollere

Patrick D Dugan

Frederick E Shelton, IV

Jeffrey S Swayze

Foster B Stulen

Matthew C Miller

David A Witt

Eugene L Timperman

Christopher W Widenhouse

Prasanna Malaviya

Mark H Ransick

James A Woodard, Jr

Agnieszka Seyda

Peter K Shires

Joseph P Schowalter

Barbara L Mattson

Takashi Kurokawa

A tissue harvesting and processing apparatus comprises a body and a distally extending needle. The needle includes an aperture configured to receive tissue. A tissue cutting member is movable relative to the needle to sever a specimen from tissue protruding through the aperture. A tissue processor is operable to mince tissue severed by the tissue cutting member. The minced tissue may be mixed with a medical fluid component contained in a reservoir. The medical fluid mixture may be expelled through an applier tip coupled with the body. The tissue processor may comprise a mincing die such that tissue specimens are minced upon being extruded through the mincing die. The tissue processor may comprise a blade that cooperates with a sliding press. The tissue processor may comprise auger blade sections that cooperate with inwardly extending pins. A mixing piston may mix the minced tissue with the medical fluid component.

Instrument for applying therapeutic cells, with proximal portion for processing therapeutic cells

A surgical device comprises a housing, a plurality of media reservoirs, an end effector, and a pumping device. Each media reservoir is configured to receive at least one component of a tissue repair composition. The end effector is configured for insertion into a lumen to deliver a tissue repair composition into that lumen. The end effector has at least one fluid conduit and at least one orifice in communication with the fluid conduit. The pumping device is operable to urge a tissue repair composition comprising at least a portion of the contents of the plurality of media reservoirs through the fluid conduit of the end effector such that the tissue repair composition is expelled from the at least one orifice. The media reservoirs may contain medical fluid components such as viable cells and scaffold material to repair a fistula or address some other condition in a patient.

Multi-chamber therapeutic cell applicator instrument

A surgical device comprises a housing, a bioprocessing module, an end effector, and a pumping device. The bioprocessing module comprises media reservoirs, fluid conduits in communication with the reservoirs, and a port through which media is expelled. The end effector is configured for insertion into a lumen and delivering a tissue repair composition into that lumen. The end effector has at least one fluid conduit extending therethrough and at least one orifice in communication with the fluid conduit. The fluid conduit in the first end effector is in fluid communication with the port on the bioprocessing module. The pumping device is operable to urge a tissue repair composition comprising at least a portion of the contents of the media reservoirs through the fluid conduit of the first end effector such that the tissue repair composition is expelled from the at least one orifice.

Therapeutic cell applicator instrument with modular tips

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Foxborough, MA, United States of America

Shelby L Cook Kornbluth