Bayer Cropscience Gmbh

Bayer Cropscience Ag

Shekhar Kulkarni

Eric Rivadeneira

Joe J Hanson

Klaus Stroech

David M Mayes

The disclosure provides for methods for preparing 2-cyanoimino-1,3-thiazolidine, which is an important building block for the preparation of crop protection active ingredients and pharmaceuticals. To this end, the disclosure provides for more efficient and improved methods of preparing 2-cyanoimino-1,3-thiazolidine.

Procedure for the preparation of 2-cyanoimino-1,3-thiazolidine

The present invention provides a method of preparing 1-acetyl-1-chlorocyclopropane from 1,3 dichloro-2-pentanone by reaction with base in the presence of a phase transfer catalyst. The reaction may be run in the presence or absence of an organic solvent and in a continuous or batch process.

Method of preparing 1-acetyl-1-chlorocyclopropane

The present invention relates to a method for the preparation of as 1-(4-Chlorophenyl)-4,4-dimethylpent-1-ene-3-one, also known as Phenyl aldol. The process of the present invention utilizes catalysts. The process enables the manufacture of the Phenyl aldol in the absence of a solvent and without crystalization or filtration steps. Yields in the range of about greater than 95% with purities in the range of about greater than 95% have been obtained with the present invention.

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Overland Park, KS, United States of America

Shekhar Kulkarni