King Fahd University of Petroleum and Minerals

Sheena Shashikanth

Katharigatta N Venugopala

Mohamed A Morsy

Sandeep Chandrashekharappa

Mahesh Attimarad

Anroop B Nair

Nagaraja Sreeharsha

Christophe Tratrat

Pran Kishore Deb

Bandar Aldhubiab

Melendran Pillay

Vijaykumar Uppar

Basavaraj Padmashali

Gabriella Marucci

Buccioni Michela

Bandar Adlhubiab

Adenosine receptor active compounds including 1,2,3,6,8-pentasubstituted indolizines and methods of using the same for inhibiting adenosine receptor activity are provided. These methods can be used to treat one or more pathological conditions of the central and peripheral nervous systems, such as but not limited to allergies, inflammation, glaucoma, brain ischemia, renal fibrosis, cancer, rheumatoid arthritis, psoriasis fatty liver diseases, stroke, pain, and any combination thereof.

Adenosine receptor activity of methyl/ethyl 3-(substituted benzoyl)-6,8-dimethylindolizine-2-substituted-1-carboxylates

Compounds for treating tuberculosis and, particularly, anti-tubercular compounds that are ethyl 2-substitued-1-(substitutedbenzoyl)-7-methylpyrrolo[1,2-a]quinoline-3-carboxylate derivatives and their use as anti-tubercular agents are provided.

Ethyl 2-substituted-1-(substitutedbenzoyl)-7-methylpyrrolo[1,2-a]quinoline-3-carboxylate derivatives as anti-tubercular agents

Compounds for treating tuberculosis and, particularly, to anti-tubercular compounds that are phenyl quinolin-1-ium bromide derivatives and their use as anti-tubercular agents.

Substituted phenyl quinolin-l-ium bromide derivative as anti-tubercular agents

Compounds for treating tuberculosis and, particularly, anti-tubercular compounds that are ethyl 2-substituted-1-(substitutedbenzoyl)-7-methylpyrrolo[1,2-a]quinoline-3-carboxylate derivatives and their use as anti-tubercular agents are provided.

The substituted indolizine dicarboxylates are antibacterial agents. The emergence of drug-resistant bacteria calls for constant development of new antibacterial agents with the aim of generating medicaments that are potent against drug sensitive and resistant bacteria and are well tolerated. The present compounds are not only new, but have very valuable antimicrobial properties. These compounds showed a broad spectrum of activity against tuberculosis mycobacteria. Based on their pharmacological profiles, the present compounds may find important clinical applications for severe infectious diseases and tuberculosis.

7-isopropyl 1-ethyl/methyl 3-(substituted benzoyl)-2-substituted indolizine-1,7-dicarboxylates as anti-tubercular agents

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Mysore, India

Sheena Shashikanth