Intrexon Corporation

Codexis, Inc.

Precigen, Inc.

Sheela Muley

Eli S Groban

William J Coleman

Genevieve M Vidanes

Guillaume Cottarel

Roy Kamimura

Akbar F Javan

Jianping Sun

Xiyun Zhang

Jack S Liang

John M Gruber

Benjamin Mijts

Lisa Marie Newman

Michael D Clay

James Joseph LaLonde

Jagadeesh Mavinahalli

Roger Arthur Sheldon

John D Munger, Jr

Jeffrey Colbeck

Jun Zhu

Jian Ding

James LaLonde

Multi-carbon compounds such as ethanol, n-butanol, sec-butanol, isobutanol, tert-butanol, fatty (or aliphatic long chain) alcohols, fatty acid methyl esters, 2,3-butanediol and the like, are important industrial commodity chemicals with a variety of applications. The present invention provides metabolically engineered host microorganisms which metabolize methane (CH) as their sole carbon source to produce multi-carbon compounds for use in fuels (e.g., bio-fuel, bio-diesel) and bio-based chemicals. Furthermore, use of the metabolically engineered host microorganisms of the invention (which utilize methane as the sole carbon source) mitigate current industry practices and methods of producing multi-carbon compounds from petroleum or petroleum-derived feedstocks, and ameliorate much of the ongoing depletion of arable food source 'farmland' currently being diverted to grow bio-fuel feedstocks, and as such, improve the environmental footprint of future bio-fuel, bio-diesel and bio-based chemical compositions.

Biological production of multi-carbon compounds from methane

The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M', and Rare as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.

Biocatalytic processes for the preparation of stereomerically pure fused bicyclic proline compounds

The present disclosure provides monoamine oxidase enzymes and methods of their use in biocatalytic processes for the preparation of substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M', and Rare as described herein.

Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds

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Fremont, CA, United States of America

Sheela Muley