Somalogic, Incorporated

Otsuka Pharmaceutical Company, Limited

Sheela M Waugh

Nebojsa Janjic

Thale Jarvis

Amy D Gelinas

John C Rohloff

Daniel W Drolet

Chi Zhang

Daniel J Schneider

Daniel I Resnicow

Thale C Jarvis

Sheri K Wilcox

Toshihide Ono

Shashi Gupta

Jonathan Vaught

Yuichi Ishikawa

Akira Nagabukuro

Akihiko Hisaminato

Ikuo Murakami

Tomoki Suzuki

Masao Hirota

Amy Gelinas

Daniel Resnicow

Aptamers that bind PDGF and aptamers that bind VEGF are provided. In addition, aptamer constructs comprising a PDGF aptamer and a VEGF aptamer are provided. Pharmaceutical compositions comprising the aptamers and aptamer constructs are provided, as well as methods of treating conditions using the aptamers and aptamer constructs.

Post-selex modification methods

Post-selec modification methods

Aptamers to PDGF and VEGF and their use in treating PDGF and VEGF mediated conditions

The present disclosure relates generally to the field of nucleic acids and, more particularly, to aptamers capable of binding to 4-1BB; pharmaceutical compositions comprising such 4-1BB aptamers; and methods of making and using the same.

Aptamers to 4-1BB and their use in treating diseases and disorders

Aptamers that bind IL-6 are provided. Pharmaceutical compositions comprising IL-6 aptamers are provided, as well as methods of treating conditions using the aptamers are also provided.

Aptamers that bind to IL-6 and their use in treating or diagnosing IL-6 mediated conditions

The present disclosure relates generally to the field of nucleic acids and, more particularly, to aptamers capable of binding to &#x3b2;-NGF; pharmaceutical compositions comprising such &#x3b2;-NGF aptamers; and methods of making and using the same.

Aptamers to &#x3b2;-NGF and their use in treating &#x3b2;-NGF mediated diseases and disorders

Growing community of inventors

Erie, CO, United States of America

Sheela M Waugh