Nanjing Nutrabuilding Bio-tech Co., Ltd.

Ortho-nutra, LLC

Ingenious Ingredients, LP

Keto Patent Group, Inc.

Keto Innovations, LLC

Axcess Global Sciences, LLC

Shawn Wells

Kylin Liao

Hector L Lopez

Tim N Ziegenfuss

Mingru Wang

Ronghua Yi

Qiru Fan

Jacob Wilson

Ryan Lowery

Martin Purpura

Joseph L Evans

Anton F Fliri

Terry LaCore

Brian Underwood

Ralf Jäger

Ralf Jaeger

Kylin Lao

Qilin Liao

Christopher N Harding

Terry Lacore

Chistopher N Harding

Among others, the present disclosure provides methods for extending lifespan or improving healthspan in a mammal, which includes administration to the mammal of a composition containing an effective amount of ergothioneine, or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof.

Use of ergothioneine for extending lifespan or improving healthspan

The present invention provides novel methods for anti-glycation, especially mitigating or preventing skin aging in a mammal, the method includes administration to the mammal of a composition including an effective amount of dihydroberberine (DHB) or its analog or its derivatives. The present invention also provides a composition including an effective amount of dihydroberberine (DHB) or its analog or its derivatives, for mitigating or preventing 'Maillard reaction' in a mammal by controlling blood glucose, scavenging chronic ROS, reducing a level of MDA and expression of MMP-1. In addition, the present invention provides method for preparing any compositions disclosed herein.

Use of dihydroberberine or its derivatives for anti-glycation

The disclosed compositions, systems and methods relate to a dietary supplement for human consumption and comprises 1-methylxanthine and optionally other compounds that modulate the effects of 1-methylxanthine. Uses for the 1-methylxanthine-containing supplements contain improvement of at least one of endurance performance, mood, vigor, lipolysis, energy expenditure, exercise performance, and/or decreased appetite.

1-methylxanthine-based bioactive composition and method of use thereof

Among others, the present invention provides methods and compositions for controlling blood glucose or weight, including a combination of (i) a therapeutically effective amount of berberine (BBR), or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof, including dihydroberberine (DHB); and (ii) vitamin B12. The combination effectively ameliorates BBR or DHB side effects, including VB12 reduction, gastrointestinal discomfort, and slowed bowel movements, by promoting transcobalamin II receptors synthesis, decreasing homocysteine levels and maintaining intestinal balance, including short chain fatty acids content, gut microbiota diversity and richness.

Combination of berberine and derivatives thereof, and vitamin B12

The present invention provides novel methods for enhancing muscle function in a mammal, the method includes administration to the mammal of a composition comprising therapeutically effective amount of dihydroberberine (DHB) or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof. The present invention also provides a composition including therapeutically effective amount of dihydroberberine (DHB) or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof, for enhancing muscle function. In addition, the present invention provides methods for preparing any compositions disclosed herein.

Use of dihydroberberine or its derivatives to enhance muscle function

Compositions of &#x3b2;-aminoisobutyric acid (BAIBA), and methods of using the same to achieve a physiological objective, are provided. Compositions of BAIBA having enantiomeric purity, in which a selected proportion of the BAIBA is L-&#x3b2;-aminoisobutyric acid (L-BAIBA) and/or a selected proportion of the BAIBA is D-&#x3b2;-aminoisobutyric acid (D-BAIBA), are also provided.

Compositions of &#x3b2;-aminoisobutyric acid and methods for use thereof

A human dietary supplement comprises theacrine and optionally other compounds that modulate the effects of theacrine. Uses for the theacrine-containing supplement include improvement of at least one of mood, energy, focus, concentration or sexual desire or a reduction of at least one of anxiety or fatigue. A synergistic composition comprises co-administration of theacrine and caffeine, wherein the co-administered caffeine reduces theacrine oral clearance (CL/F) and oral volume of distribution (Vd/F). In addition, the co-administered caffeine increases area under the plasma concentration time curve (AUC) of theacrine, and increases theacrine maximum plasma concentration (C) in comparison with the corresponding pharmacokinetic parameters when theacrine is administered alone.

Theacrine-based supplement and method of use thereof in a synergistic combination with caffeine

Among others, the present invention provides novel methods for extending lifespan or improving healthspan in a mammal, which include administration to the mammal of a composition containing a therapeutically effective amount of ergothioneine, or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof.

Glutathione deficiencies and deficiencies in glutathione synthetase activity, and therapeutic methods for the treatment thereof.

Methods of treating glutathione deficiencies and deficiencies in glutathione synthetase activity

The present disclosure pertains to compositions and methods for the treatment and/or prevention of one or more of obesity, diabetes, metabolic syndrome, Alzheimer's disease, Chronic Fatigue Syndrome (CFS), aging, fibromyalgia, dyslipidemia, hypercholesterolemia, dyslipidemia, Parkinson's disease, migraines, Traumatic Brain Injury (TBI), Attention Deficit Disorder (ADD)/Attention Deficit Hyperactivity Disorder (ADHD), Cancer, Cardiovascular Disease (CVD)/Coronary Artery Disease (CAD), Chronic Pain, neuralgia, depression, amyotrophic lateral sclerosis (ALS), and epilepsy, Insufficient Cellular Energy (ICE) and mitochondrial dysfunction. The present disclosure also pertains to methods for increasing mental and/or physical performance levels and/or decreasing exertion during exercise in a subject by the administration of C5 ketones.

C5 ketone compositions, and related methods, for therapeutic and performance supplementation

The disclosed compositions and methods relate to the increasing muscle mass, preventing muscle atrophy, promoting muscle growth, as well as treatment of various other conditions and diseases. In certain aspects, the disclosed compositions are comprised dileucine and leucine and pharmaceutically acceptable salts thereof. In certain aspects, disclosed compositions are administered to subjects in need thereof to increase muscle mass, prevent muscle atrophy, and/or promote muscle growth.

Compositions and methods of use thereof to promote muscle growth and function

In various implementations, berberine metabolites, such as dihydroberberine and/or tetrahydroberberine, may be administered to manage blood glucose levels, increase ketone levels (e.g., blood concentration of ketones), and/or for therapeutic purposes in humans. The administration of a pharmaceutically effective amount of berberine metabolites, such as dihydroberberine, may reduce fasting blood glucose levels, improve glucose tolerance, and/or improve blood ketone response. In some implementations, berberine metabolites may be administered with one or more other compounds.

Administration of berberine metabolites

A human dietary supplement comprises theacrine and optionally other compounds that modulate the effects of theacrine. Uses for the theacrine-containing supplement include improvement of at least one of mood, energy, focus, concentration or sexual desire or a reduction of at least one of anxiety or fatigue.

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Lewisville, TX, United States of America

Shawn Wells