Leland Stanford Junior University

Shawn L Chavez

Barry Behr

Renee Ann Reijo Pera

David B Camarillo

Jinnuo Han

Livia Zarnescu

Kevin E Loewke

Lynn M Westphal

Brooke Friedman

Sohyun L McElroy

Renee A Reijo Pera

Provided are methods for the determination of the viability of a mammalian embryo or a potential embryo generated from a mammalian oocyte, comprising applying a mechanical stimulus to the embryo or oocyte, detecting a temporal response of the embryo or oocyte to the mechanical stimulus, and deriving measurements for one or more parameters from the temporal response, the measurements being indicative of viability. Also provided are methods for selecting an embryo for transfer and methods for enhancing the viability of an embryo or oocyte.

Mechanical biomarkers for oocyte and embryo viability

Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.

Methods of detecting aneuploidy in human embryos

Markers are provided for genetic and epigenetic diagnosis of embryos to determine those of which are more likely to be chromosomally normal and advance in development.

Markers for the detection of human embryo developmental quality

Methods are provided for the non-invasive imaging of embryos to determine whether they are euploid or aneuploid.

Non-invasive imaging to the blastocyst stage for the detection of human embryonic aneuploidy

Growing community of inventors

Fremont, CA, United States of America

Shawn L Chavez