Northwestern University

Shawn G Anthony

Samuel I Stupp

Heather Behanna

Jack J J M Donners

Gabriel A Silva

Erik David Spoerke

Krista L Niece

Heather A Behanna

Amphiphilic peptide compounds comprising one or more epitope sequences for binding interaction with one or more corresponding growth factors, micellar assemblies of such compounds and related methods of use.

Self-assembling peptide amphiphiles and related methods for growth factor delivery

The present invention provides a system of self-assembling peptide amphiphiles with an absolute net charge of 3 or greater whose design and function may be patterned after proteins involved in vertebrate mineralization or other tissue forming processes. This molecular system preferably consists of a hydrophobic hydrocarbon tail attached to a relatively hydrophilic peptide sequence. Self-assembly of this peptide amphiphile may be induced through pH variation, divalent ion addition, or dehydration. Variations of structural peptide sequences in the peptide amphiphile may enable the assembled nanofibers to be reversibly cross-linked for more or less structural stability, or may allow for control of the rate of self-assembly.

Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom

Biocompatible composites comprising peptide amphiphiles and surface modified substrates and related methods for attachment thereon.

Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon

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New Stanton, PA, United States of America

Shawn G Anthony