Pfizer Corporation

Shawn Cabral

Kentaro Futatsugi

David Hepworth

Kim Huard

Markus Boehm

Robert L Dow

David W Piotrowski

Ariamala Gopalsamy

Matthew Scott Dowling

Esther Cheng Yin Lee

Ralph Pelton Robinson, Jr

Allyn T Londregan

Mihir D Parikh

Jana Polivkova

Qifang Li

Chulho Choi

David A Price

Olugbeminiyi Omezia Fadeyi

Arjun Venkat Narayanan

Hatice Gizem Yayla

Jayasankar Jasti

Ming Zhu Chen

Lee Richard Roberts

Lyn Howard Jones

Agustin Casimiro-Garcia

Philip Albert Carpino

Suvi Tuula Marjukka Orr

Daniel Wei-Shung Kung

Daniel W Kung

Suvi Orr

Jian Wang

Agustin Casimiro Garcia

Kun Song

Kay Ahn

The invention relates to pyrazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to HbS modulators of formula (I) HbS modulators are potentially useful in the treatment of a wide range of disorders, including sickle cell disease (SCD).

Chemical compounds

Compounds of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein.

Diacylglycerol acyl transferase 2 inhibitors

The invention relates to pyrazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to HbS modulators of formula (I) or tautomers thereof, or pharmaceutically acceptable salts of said modulators or tautomers thereof, wherein X, Y, Rand Rare as defined in the description. HbS modulators are potentially useful in the treatment of a wide range of disorders, including sickle cell disease (SCD).

Diacylglycerol acyltransferase 2 inhibitors

Derivatives of purine, 3H-imidazo[4,5-b]pyrimidine and 1H-imidazo[4,5-d]pyrazine of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein.

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Groton, CT, United States of America

Shawn Cabral