Alkem Laboratories Limited

Shashiprabha

Kuppuswamy Nagarajan

Kothapalli Sundarraja Rao

Shridhara Kanakamajalu

K Sundarraja Rao

Padmashree Badraje

Sanjay Sukumar Saralya

Shashikumar Hiriyalu Somashekar

Akshaya Kunjyannaya

Kanakamajalu Shridhara

Koottungalmadhom Ramaswamy Ranganathan

Veerasamy Ananthalakshmi

Sanjay Sukumar Saralaya

Debkiron Mukherjee

Govindarajalu Jeyaraman

The present invention relates to atovaquone prodrug compound of formula (I). Accordingly, present invention provides a process involving condensation of Atovaquone (II) with 5-methyl-4-chloromethyl dioxalone (III) in suitable solvent system and optionally followed by distillation and crystallization to provide Atovaquone prodrug compound of formula (I) in high yields, purity, and suitable for large-scale manufacture.

3-(5-methyl-2-oxo-l, 3-dioxol-4-yl) methyloxy-2-trans-[(4-chloro phenyl) cyclohexyl][1,4]naphthaquinone-atovaquone prodrug

The present invention relates to a process for preparing Ziprasidone of formula I, or a pharmaceutically acceptable salt or a solvate or a hydrate thereof;comprising the steps of reacting 1-(1,2-benzisothiazol-3-yl) piperazine of formula II or its salt: with 5-(2-haloethyl)-6-chloro-oxindole of formula III: wherein X is leaving groups like fluoro, chloro, bromo, iodo or sulphonyl;in the presence of a dispersing agent and a base in a solvent to form ziprasidone of formula I; and optionally converting the ziprasidone formed into a pharmaceutically acceptable acid addition salts of ziprasidone; or a solvate or a hydrate thereof.

Process for the preparation of ziprasidone

The present invention relates the use of 2,3-dihalonaphthoquinone compounds of Formula I wherein Rand Rare leaving groups like halogens selected from the group comprising Cl, Br, I and F and the Rand Rmay be the same halogen or may contain different halogen groups, or sulphonyl groups, for making napthoquinone compounds of Formula IA wherein X is any aryl, heteroaryl, alkyl, cyclohexyl, substituted cylohexyl groups and the like.

Preparation of naphthoquinone compounds using 2,3-dihalonaphthoquinone

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Bengaluru, India

Shashiprabha