Somalogic, Incorporated

Otsuka Pharmaceutical Company, Limited

Somalogic Operating Co., Inc.

Shashi Gupta

Daniel J Schneider

Larry M Gold

Bruce Eaton

Dominic Zichi

Dan Nieuwlandt

Stephan Kraemer

Nebojsa Janjic

Martin Stanton

Thale Jarvis

Daniel W Drolet

Amy D Gelinas

Chi Zhang

Sheela M Waugh

Marty Stanton

Ikuo Murakami

Daniel J O'Connell

Tomoki Suzuki

Masao Hirota

Yuichi Ishikawa

Thale C Jarvis

Amy Gelinas

Daniel J O'connell

Described herein are aptamers capable of binding to human complement component 3 (C3) protein; compositions comprising a C3 binding aptamer with a C3-Protein; and methods of making and using the same.

Nucleic acid compounds for binding to complement component 3 protein

The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non-nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.

Multiplexed analyses of test samples

Aptamers that bind IL-6 are provided. Pharmaceutical compositions comprising IL-6 aptamers are provided, as well as methods of treating conditions using the aptamers are also provided.

Aptamers that bind to IL-6 and their use in treating or diagnosing IL-6 mediated conditions

The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.

Growing community of inventors

Louisville, CO, United States of America

Shashi Gupta